Guardians vs. Padres Prediction: San Diego Predicted to Win Wednesday's MLB Matchup [4/2/2025]

The San Diego Padres will take on the Cleveland Guardians in MLB action at PETCO Park on Wednesday, starting at 4:10PM ET.

The Padres will start Dylan Cease (0-0, 6.23 ERA), up against Ben Lively (0-0, 5.40 ERA) for the Guardians.

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Padres as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Cleveland-San Diego game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Padres' chance of winning at 64%, with the Guardians at 36%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Guardians vs. Padres predictions page.

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Guardians vs. Guardians Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the outcome of Wednesday's MLB game between the Guardians and Padres 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Padres a 64% chance of beating the Guardians.

According to our model, the Guardians (+1.5) have a 54% chance of covering the run line, while the over/under total of 7.5 runs has a 53% chance of going over.

Pre-Game Probabilities

Last Updated: 8:27PM, Apr 2

Moneyline

Over / Under

Run Line

Guardians

Win %

36%

64%

+170

-185

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Padres

Guardians CLE

+170

Win %

36%

64%

See Matchup

Padres SD

-185

Ben Lively 0-0, 5.40 ERA

Dylan Cease 0-0, 6.23 ERA

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Guardians vs. Padres Odds [4/2/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Guardians vs. Padres Picks and Best Bets

Our model's biggest edge in today's Guardians vs. Padres matchup is on the over/under.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Guardians vs. Padres Game-Day Updates and Essential Details

Wednesday's MLB matchup between the Padres and Guardians at PETCO Park is scheduled to start at 4:10PM ET.

• Who: Cleveland Guardians vs. San Diego Padres
• Date: Wednesday, April 2, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: PETCO Park

Dimers.com's comprehensive preview of Wednesday's Guardians vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Cleveland vs. San Diego picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 64% win probability, will likely beat the Guardians on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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