Guardians vs. Padres Prediction: San Diego Predicted to Win Monday's MLB Matchup [3/31/2025]

The San Diego Padres will square off with the Cleveland Guardians in MLB action at PETCO Park on Monday, beginning at 9:40PM ET.

Kyle Hart (0-0, 0.00 ERA) will start on the mound for the Padres, while the Guardians are going with Luis L. Ortiz (0-0, 0.00 ERA).

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's Cleveland-San Diego game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Padres are likely to win, with a probability of 56%, compared to the Guardians' 44%."

For a closer look at Monday's matchup, including best bets and picks, visit our interactive Guardians vs. Padres predictions page.

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Guardians vs. Guardians Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the result of Monday's MLB matchup between the Guardians and Padres 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Padres a 56% chance of defeating the Guardians.

According to our model, the Guardians (+1.5) have a 62% chance of covering the run line, while the 8-run over/under has a 53% chance of going over.

Pre-Game Probabilities

Last Updated: 1:28AM, Apr 1

Moneyline

Over / Under

Run Line

Guardians

Win %

43%

57%

+115

-130

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Padres

Guardians CLE

+115

Win %

43%

57%

See Matchup

Padres SD

-130

Luis Ortiz 0-0, 0.00 ERA

Kyle Hart 0-0, 0.00 ERA

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Guardians vs. Padres Odds [3/31/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Padres Picks and Best Bets

Our model's strongest edge in today's Guardians vs. Padres matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Guardians vs. Padres Game-Day Updates and Essential Details

Monday's MLB action between the Padres and Guardians at PETCO Park is scheduled to start at 9:40PM ET.

• Who: Cleveland Guardians vs. San Diego Padres
• Date: Monday, March 31, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers.com's in-depth preview of Monday's Guardians vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Cleveland vs. San Diego picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 56% win probability, will likely beat the Guardians on Monday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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