Diamondbacks vs. Nationals Prediction: Arizona Predicted to Win Friday's MLB Matchup [4/4/2025]

The Washington Nationals will face the Arizona Diamondbacks in MLB action at Nationals Park on Friday, beginning at 6:45PM ET.

The Nationals will start Jake Irvin (0-0, 3.60 ERA), while the Diamondbacks have opted for Brandon Pfaadt (0-1, 4.50 ERA).

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) projects the Diamondbacks as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Arizona-Washington game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Diamondbacks' chance of winning is 55%, while the Nationals' is 45%."

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Diamondbacks vs. Nationals predictions page.

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Diamondbacks vs. Diamondbacks Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data analysis, we have simulated the outcome of Friday's MLB matchup between the Diamondbacks and Nationals 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Diamondbacks a 55% chance of beating the Nationals.

According to our model, the Nationals (+1.5) have a 59% chance of covering the run line, while the over/under total of 8.5 runs has a 52% chance of going over.

Pre-Game Probabilities

Last Updated: 10:27PM, Apr 4

Moneyline

Over / Under

Run Line

D-Backs

Win %

55%

45%

-148

+140

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See Matchup

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Nationals

D-Backs ARI

-148

Win %

55%

45%

See Matchup

Nationals WSH

+140

Brandon Pfaadt 0-1, 4.50 ERA

Jake Irvin 0-0, 3.60 ERA

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Diamondbacks vs. Nationals Odds [4/4/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Diamondbacks vs. Nationals Picks and Best Bets

Our model's strongest edge in today's Diamondbacks vs. Nationals matchup is on the over/under.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Diamondbacks vs. Nationals Game-Day Updates and Essential Details

Friday's MLB game between the Nationals and Diamondbacks at Nationals Park is scheduled to start at 6:45PM ET.

• Who: Arizona Diamondbacks vs. Washington Nationals
• Date: Friday, April 4, 2025
• Time: 6:45PM ET/3:45PM PT
• Venue: Nationals Park

Dimers.com's comprehensive preview of Friday's Diamondbacks vs. Nationals matchup includes our prediction, picks and the latest betting odds.

Before making any Arizona vs. Washington picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Diamondbacks, with a 55% win probability, will likely beat the Nationals on Friday.

AI and automation have enhanced this article to quickly deliver accurate Diamondbacks vs. Nationals insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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