Mariners vs. Giants Prediction: San Francisco Predicted to Win Friday's MLB Matchup [4/4/2025]

The San Francisco Giants will face the Seattle Mariners in MLB action at Oracle Park on Friday, beginning at 4:35PM ET.

The Giants will have Justin Verlander (0-0, 3.60 ERA) as their starting pitcher, pitting him against Luis F. Castillo (0-0, 0.00 ERA) for the Mariners.

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Giants as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Seattle-San Francisco game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Giants' chance of winning is 58%, while the Mariners' is 42%."

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Mariners vs. Giants predictions page.

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Mariners vs. Mariners Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and statistical analysis, we have simulated the result of Friday's MLB matchup between the Mariners and Giants 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Giants a 58% chance of beating the Mariners.

According to our model, the Mariners (+1.5) have a 62% chance of covering the run line, while the 7.5-run over/under has a 53% chance of going over.

Pre-Game Probabilities

Last Updated: 8:28PM, Apr 4

Moneyline

Over / Under

Run Line

Mariners

Win %

42%

58%

+130

-148

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Giants

Mariners SEA

+130

Win %

42%

58%

See Matchup

Giants SF

-148

Luis Castillo 0-0, 0.00 ERA

Justin Verlander 0-0, 3.60 ERA

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Mariners vs. Giants Odds [4/4/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Mariners vs. Giants Picks and Best Bets

Our model's strongest edge in today's Mariners vs. Giants matchup is on the total.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Mariners vs. Giants Game-Day Updates and Essential Details

Friday's MLB matchup between the Giants and Mariners at Oracle Park is scheduled to commence at 4:35PM ET.

• Who: Seattle Mariners vs. San Francisco Giants
• Date: Friday, April 4, 2025
• Time: 4:35PM ET/1:35PM PT
• Venue: Oracle Park

Dimers.com's full preview of Friday's Mariners vs. Giants matchup includes our prediction, picks and the latest betting odds.

Before making any Seattle vs. San Francisco picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Giants, with a 58% win probability, will likely beat the Mariners on Friday.

AI and automation have enhanced this article to quickly deliver accurate Mariners vs. Giants insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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