Cubs vs. Padres Prediction: Cubs Predicted to Win Tuesday's MLB Matchup [4/15/2025]

The San Diego Padres and Chicago Cubs will meet in MLB action at PETCO Park on Tuesday, starting at 9:40PM ET.

The Padres will have Randy Vásquez (1-1, 1.72 ERA) as their starting pitcher, while the Cubs have opted for Shota Imanaga (2-1, 2.70 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's CHI Cubs-San Diego game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Cubs with a win probability of 55%, compared to 45% for the Padres."

For further insights into Tuesday's matchup, including best bets and picks, visit our interactive Cubs vs. Padres predictions page.

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Cubs vs. Cubs Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Tuesday's MLB game between the Cubs and Padres 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Cubs a 55% chance of defeating the Padres.

According to our model, the Padres (+1.5) have a 59% chance of covering the run line, while the over/under total of 8.5 runs has a 54% chance of staying under.

Pre-Game Probabilities

Last Updated: 1:28AM, Apr 16

Moneyline

Over / Under

Run Line

Cubs

Win %

55%

45%

-148

+138

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Padres

Cubs CHC

-148

Win %

55%

45%

See Matchup

Padres SD

+138

Shota Imanaga 2-1, 2.70 ERA

Randy Vásquez 1-1, 1.72 ERA

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Cubs vs. Padres Odds [4/15/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Padres Picks and Best Bets

Our model's biggest edge in today's Cubs vs. Padres matchup is on the over/under.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Cubs vs. Padres Game-Day Updates and Essential Details

Tuesday's MLB matchup between the Padres and Cubs at PETCO Park is scheduled to begin at 9:40PM ET.

• Who: Chicago Cubs vs. San Diego Padres
• Date: Tuesday, April 15, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers.com's full preview of Tuesday's Cubs vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any CHI Cubs vs. San Diego picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Cubs, with a 55% win probability, will likely beat the Padres on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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