Dodgers vs. Cubs Prediction: Cubs Predicted to Win Wednesday's MLB Matchup [4/23/2025]

The Chicago Cubs and Los Angeles Dodgers will lock horns in MLB action at Wrigley Field on Wednesday, starting at 7:00PM ET.

Matthew Boyd (1-2, 2.02 ERA) will start on the mound for the Cubs, pitting him against Ben Casparius (2-0, 4.11 ERA) for the Dodgers.

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's LA Dodgers-CHI Cubs game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Cubs' chance of winning at 52%, with the Dodgers at 48%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Dodgers vs. Cubs predictions page.

Get 20% off Dimers Pro With Code 20BASEBALL

Get Dimers Pro

Cubs vs. Dodgers Prediction: Who Will Win?

Using powerful machine learning and data analysis, we have simulated the outcome of Wednesday's MLB matchup between the Dodgers and Cubs 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Cubs a 52% chance of beating the Dodgers.

According to our model, the over/under total of 9 runs has a 51% chance of staying under.

Pre-Game Probabilities

Last Updated: 11:28PM, Apr 23

Moneyline

Over / Under

Dodgers

Win %

48%

52%

+115

-125

Get the best bets with Dimers Pro

See Matchup

Get Dimers Pro

Cubs

Dodgers LAD

+115

Win %

48%

52%

See Matchup

Cubs CHC

-125

Ben Casparius 2-0, 4.11 ERA

Matthew Boyd 1-2, 2.02 ERA

Get the best bets with Dimers Pro

Get Dimers Pro

Dodgers vs. Cubs Odds [4/23/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Dodgers vs. Cubs Picks and Best Bets

Our model's strongest edge in today's Dodgers vs. Cubs matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Unlock Every Dodgers-Cubs Pick

Get Dimers Pro

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Dodgers vs. Cubs Game-Day Updates and Essential Details

Wednesday's MLB action between the Cubs and Dodgers at Wrigley Field is scheduled to start at 7:00PM ET.

• Who: Los Angeles Dodgers vs. Chicago Cubs
• Date: Wednesday, April 23, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: Wrigley Field

Dimers.com's comprehensive preview of Wednesday's Dodgers vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any LA Dodgers vs. CHI Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Cubs, with a 52% win probability, will likely beat the Dodgers on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Dodgers vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay up-to-date with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most up-to-date probabilities for the World Series, American League, National League and each division.