Cubs vs. Padres Prediction: San Diego Predicted to Win Monday's MLB Matchup [4/14/2025]

The San Diego Padres will face the Chicago Cubs in MLB action at PETCO Park on Monday, commencing at 9:40PM ET.

Dylan Cease (1-1, 7.98 ERA) will start for the Padres, while the Cubs have opted for Jameson Taillon (1-1, 6.06 ERA).

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's CHI Cubs-San Diego game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Padres are likely to win, with a probability of 60%, compared to the Cubs' 40%."

For a closer look at Monday's matchup, including best bets and picks, visit our interactive Cubs vs. Padres predictions page.

Get 20% off Dimers Pro With Code 20BASEBALL

Get Dimers Pro

Cubs vs. Cubs Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and statistical analysis, we have simulated the result of Monday's MLB matchup between the Cubs and Padres 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Padres a 60% chance of defeating the Cubs.

According to our model, the Cubs (+1.5) have a 60% chance of covering the run line, while the over/under total of 7.5 runs has a 51% chance of going over.

Pre-Game Probabilities

Last Updated: 1:28AM, Apr 15

Moneyline

Over / Under

Run Line

Cubs

Win %

40%

60%

+126

-148

Get the best bets with Dimers Pro

See Matchup

Get Dimers Pro

Padres

Cubs CHC

+126

Win %

40%

60%

See Matchup

Padres SD

-148

Jameson Taillon 1-1, 6.06 ERA

Dylan Cease 1-1, 7.98 ERA

Get the best bets with Dimers Pro

Get Dimers Pro

Cubs vs. Padres Odds [4/14/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Cubs vs. Padres Picks and Best Bets

Our model's strongest edge in today's Cubs vs. Padres matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Unlock Every Cubs-Padres Pick

Get Dimers Pro

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Cubs vs. Padres Game-Day Updates and Essential Details

Monday's MLB matchup between the Padres and Cubs at PETCO Park is scheduled to begin at 9:40PM ET.

• Who: Chicago Cubs vs. San Diego Padres
• Date: Monday, April 14, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers.com's in-depth preview of Monday's Cubs vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any CHI Cubs vs. San Diego picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 60% win probability, will likely beat the Cubs on Monday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay up-to-date with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest probabilities for the World Series, American League, National League and each division.