Cardinals vs. Red Sox Prediction: Boston Predicted to Win Friday's MLB Matchup [4/4/2025]

The Boston Red Sox will take on the St. Louis Cardinals in MLB action at Fenway Park on Friday, beginning at 2:10PM ET.

The Red Sox will send Walker Buehler (0-1, 8.31 ERA) to the mound, pitting him against Erick Fedde (1-0, 1.50 ERA) for the Cardinals.

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Red Sox as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's St. Louis-Boston game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Red Sox' chance of winning is 55%, while the Cardinals' is 45%."

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Cardinals vs. Red Sox predictions page.

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Cardinals vs. Cardinals Prediction: Who Will Win?

Using trusted machine learning and data, we have simulated the result of Friday's MLB matchup between the Cardinals and Red Sox 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Red Sox a 55% chance of beating the Cardinals.

According to our model, the 9.5-run over/under has a 53% chance of staying under.

Pre-Game Probabilities

Last Updated: 6:28PM, Apr 4

Moneyline

Over / Under

Run Line

Cardinals

Win %

45%

55%

+100

-115

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Red Sox

Cardinals STL

+100

Win %

45%

55%

See Matchup

Red Sox BOS

-115

Erick Fedde 1-0, 1.50 ERA

Walker Buehler 0-1, 8.31 ERA

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Cardinals vs. Red Sox Odds [4/4/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Red Sox Picks and Best Bets

Our model's biggest edge in today's Cardinals vs. Red Sox matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Cardinals vs. Red Sox Game-Day Updates and Essential Details

Friday's MLB game between the Red Sox and Cardinals at Fenway Park is scheduled to begin at 2:10PM ET.

• Who: St. Louis Cardinals vs. Boston Red Sox
• Date: Friday, April 4, 2025
• Time: 2:10PM ET/11:10AM PT
• Venue: Fenway Park

Dimers.com's in-depth preview of Friday's Cardinals vs. Red Sox matchup includes our prediction, picks and the latest betting odds.

Before making any St. Louis vs. Boston picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Red Sox, with a 55% win probability, will likely beat the Cardinals on Friday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Red Sox insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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