Giants vs. Astros Prediction: San Francisco Predicted to Win Tuesday's MLB Matchup [4/1/2025]

The Houston Astros will take on the San Francisco Giants in MLB action at Daikin Park on Tuesday, starting at 8:10PM ET.

The Astros will send Hayden Wesneski (0-0, 0.00 ERA) to the mound, pitting him against Logan Webb (0-0, 5.40 ERA) for the Giants.

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Giants as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's San Francisco-Houston game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Giants with a win probability of 51%, compared to 49% for the Astros."

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive Giants vs. Astros predictions page.

EXCLUSIVE OFFER: Sign up to Dimers Pro with code MARCH today to enjoy a full month for the price of just one week!

Get Your First Month For the Price of 1 Week with Promo Code MARCH

Get Dimers Pro

Giants vs. Giants Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the outcome of Tuesday's MLB matchup between the Giants and Astros 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Giants a 51% chance of defeating the Astros.

According to our model, the Astros (+1.5) have a 63% chance of covering the run line, while the 8-run over/under has an equal 50-50 chance of hitting.

Pre-Game Probabilities

Last Updated: 12:28AM, Apr 2

Moneyline

Over / Under

Run Line

Giants

Win %

52%

48%

-134

+120

Get the best bets with Dimers Pro

See Matchup

Get Dimers Pro

Astros

Giants SF

-134

Win %

52%

48%

See Matchup

Astros HOU

+120

Logan Webb 0-0, 5.40 ERA

Hayden Wesneski 0-0, 0.00 ERA

Get the best bets with Dimers Pro

Get Dimers Pro

Giants vs. Astros Odds [4/1/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Giants vs. Astros Picks and Best Bets

Our model's biggest edge in today's Giants vs. Astros matchup is on the total.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Unlock Every Giants-Astros Pick

Get Dimers Pro

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Giants vs. Astros Game-Day Updates and Essential Details

Tuesday's MLB matchup between the Astros and Giants at Daikin Park is scheduled to commence at 8:10PM ET.

• Who: San Francisco Giants vs. Houston Astros
• Date: Tuesday, April 1, 2025
• Time: 8:10PM ET/5:10PM PT
• Venue: Daikin Park

Dimers.com's full preview of Tuesday's Giants vs. Astros matchup includes our prediction, picks and the latest betting odds.

Before making any San Francisco vs. Houston picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Giants, with a 51% win probability, will likely beat the Astros on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay up-to-date with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest projections for the World Series, American League, National League and each division.