Giants vs. Reds Prediction: Cincinnati Predicted to Win Saturday's MLB Matchup [3/29/2025]

The Cincinnati Reds and San Francisco Giants are scheduled to meet in MLB action at Great American Ball Park on Saturday, starting at 4:10PM ET.

The Reds will send Nick Lodolo (0-0, 0.00 ERA) to the mound, up against Justin Verlander (0-0, 0.00 ERA) for the Giants.

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects the Reds as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's San Francisco-Cincinnati game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Reds are more likely to win, while the Giants have a lower chance of victory."

For further insights into Saturday's matchup, including best bets and picks, visit our interactive Giants vs. Reds predictions page.

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Giants vs. Giants Prediction: Who Will Win?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Saturday's MLB matchup between the Giants and Reds 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Reds a 56% chance of beating the Giants.

According to our model, the over/under total of 8.5 runs has a 51% chance of staying under.

Pre-Game Probabilities

Last Updated: 8:27PM, Mar 29

Moneyline

Over / Under

Run Line

Giants

Win %

45%

55%

+105

-118

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Reds

Giants SF

+105

Win %

45%

55%

See Matchup

Reds CIN

-118

Justin Verlander 0-0, 0.00 ERA

Nick Lodolo 0-0, 0.00 ERA

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Giants vs. Reds Odds [3/29/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Giants vs. Reds Picks and Best Bets

Our model's biggest edge in today's Giants vs. Reds matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Giants vs. Reds Game-Day Updates and Essential Details

Saturday's MLB matchup between the Reds and Giants at Great American Ball Park is scheduled to begin at 4:10PM ET.

• Who: San Francisco Giants vs. Cincinnati Reds
• Date: Saturday, March 29, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: Great American Ball Park

Dimers.com's in-depth preview of Saturday's Giants vs. Reds matchup includes our prediction, picks and the latest betting odds.

Before making any San Francisco vs. Cincinnati picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Reds, with a 56% win probability, will likely beat the Giants on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Reds insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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