Padres vs. Cubs Prediction: Cubs Predicted to Win Sunday's MLB Matchup [4/6/2025]

The Chicago Cubs will face the San Diego Padres, in what is expected to be a tight MLB game, at Wrigley Field on Sunday, starting at 2:20PM ET.

Ben Brown (1-1, 5.87 ERA) will be on the bump for the Cubs, while the Padres have opted for Kyle Hart (1-0, 3.60 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) projects the Cubs as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's San Diego-CHI Cubs game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Cubs with a win probability of 54%, while the Padres have 46%."

For further insights into Sunday's matchup, including best bets and picks, visit our interactive Padres vs. Cubs predictions page.

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Padres vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the result of Sunday's MLB matchup between the Padres and Cubs 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Cubs a 54% chance of defeating the Padres.

According to our model, the Padres (+1.5) have a 63% chance of covering the run line, while the over/under total of 7.5 runs has a 51% chance of going over.

Pre-Game Probabilities

Last Updated: 6:27PM, Apr 6

Moneyline

Over / Under

Run Line

Padres

Win %

46%

54%

+125

-130

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See Matchup

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Cubs

Padres SD

+125

Win %

46%

54%

See Matchup

Cubs CHC

-130

Kyle Hart 1-0, 3.60 ERA

Ben Brown 1-1, 5.87 ERA

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Padres vs. Cubs Odds [4/6/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Padres vs. Cubs Picks and Best Bets

Our model's biggest edge in today's Padres vs. Cubs matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Padres vs. Cubs Game-Day Updates and Essential Details

Sunday's MLB matchup between the Cubs and Padres at Wrigley Field is scheduled to begin at 2:20PM ET.

• Who: San Diego Padres vs. Chicago Cubs
• Date: Sunday, April 6, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's comprehensive preview of Sunday's Padres vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any San Diego vs. CHI Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cubs, with a 54% win probability, will likely beat the Padres on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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