Phillies vs. Nationals Prediction: Philadelphia Predicted to Win MLB Opening Day Matchup [3/27/2025]

The Washington Nationals and Philadelphia Phillies will meet on Opening Day of the 2025 MLB season at Nationals Park on Thursday, starting at 4:05PM ET.

The Nationals will have MacKenzie Gore (0-0, 0.00 ERA) as their starting pitcher, pitting him against Zack Wheeler (0-0, 0.00 ERA) for the Phillies.

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Phillies as the most likely winner of today's game.

"Using the latest data, our experts simulated Thursday's Philadelphia-Washington game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast the Phillies with a win probability of 58% and the Nationals with 42%."

For expanded analysis of Thursday's matchup, including best bets and picks, visit our interactive Phillies vs. Nationals predictions page.

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Phillies vs. Phillies Prediction: Who Will Win on MLB Opening Day?

Using innovative machine learning and data, we have simulated the outcome of Thursday's MLB game between the Phillies and Nationals 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Phillies a 58% chance of beating the Nationals.

According to our model, the Nationals (+1.5) have a 57% chance of covering the run line, while the 7-run over/under has a 56% chance of going over.

Pre-Game Probabilities

Last Updated: 8:28PM, Mar 27

Moneyline

Over / Under

Run Line

Phillies

Win %

56%

44%

-155

+136

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Nationals

Phillies PHI

-155

Win %

56%

44%

See Matchup

Nationals WSH

+136

Zack Wheeler 0-0, 0.00 ERA

MacKenzie Gore 0-0, 0.00 ERA

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Phillies vs. Nationals Odds [3/27/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Phillies vs. Nationals Picks and Best Bets

Our model's strongest edge in today's Phillies vs. Nationals matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Phillies vs. Nationals Game-Day Updates and Essential Details

Thursday's MLB matchup between the Nationals and Phillies at Nationals Park is scheduled to commence at 4:05PM ET.

• Who: Philadelphia Phillies vs. Washington Nationals
• Date: Thursday, March 27, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: Nationals Park

Dimers.com's comprehensive preview of Thursday's Phillies vs. Nationals matchup includes our prediction, picks and the latest betting odds.

Before making any Philadelphia vs. Washington picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Phillies, with a 58% win probability, will likely beat the Nationals on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Phillies vs. Nationals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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