Angels vs. Cardinals Prediction: St. Louis Predicted to Win Wednesday's MLB Matchup [4/2/2025]

The St. Louis Cardinals will face the Los Angeles Angels in MLB action at Busch Stadium on Wednesday, beginning at 1:15PM ET.

Sonny Gray (1-0, 3.60 ERA) will get the ball for the Cardinals, while the Angels have opted for Yusei Kikuchi (0-1, 4.50 ERA).

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cardinals as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's LA Angels-St. Louis game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Cardinals' chance of winning at 57%, with the Angels at 43%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Angels vs. Cardinals predictions page.

EXCLUSIVE OFFER: Sign up to Dimers Pro with code MARCH today to enjoy a full month for the price of just one week!

Get Your First Month For the Price of 1 Week with Promo Code MARCH

Get Dimers Pro

Angels vs. Angels Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data analysis, we have simulated the outcome of Wednesday's MLB matchup between the Angels and Cardinals 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Cardinals a 57% chance of defeating the Angels.

According to our model, the Angels (+1.5) have a 63% chance of covering the run line, while the over/under total of 8.5 runs has a 54% chance of staying under.

Pre-Game Probabilities

Last Updated: 5:28PM, Apr 2

Moneyline

Over / Under

Run Line

Angels

Win %

42%

58%

+130

-142

Get the best bets with Dimers Pro

See Matchup

Get Dimers Pro

Cardinals

Angels LAA

+130

Win %

42%

58%

See Matchup

Cardinals STL

-142

Yusei Kikuchi 0-1, 4.50 ERA

Sonny Gray 1-0, 3.60 ERA

Get the best bets with Dimers Pro

Get Dimers Pro

Angels vs. Cardinals Odds [4/2/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Angels vs. Cardinals Picks and Best Bets

Our model's biggest edge in today's Angels vs. Cardinals matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Unlock Every Angels-Cardinals Pick

Get Dimers Pro

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Angels vs. Cardinals Game-Day Updates and Essential Details

Wednesday's MLB action between the Cardinals and Angels at Busch Stadium is scheduled to start at 1:15PM ET.

• Who: Los Angeles Angels vs. St. Louis Cardinals
• Date: Wednesday, April 2, 2025
• Time: 1:15PM ET/10:15AM PT
• Venue: Busch Stadium

Dimers.com's in-depth preview of Wednesday's Angels vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any LA Angels vs. St. Louis picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Cardinals, with a 57% win probability, will likely beat the Angels on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Angels vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the most up-to-date probabilities for the World Series, American League, National League and each division.