Yankees vs. Guardians Prediction: Close Contest Projected After New Data Released for Tuesday's MLB Matchup [4/22/2025]

The Cleveland Guardians will square off with the New York Yankees in MLB action at Progressive Field on Tuesday, beginning at 6:10PM ET.

The Guardians will start Tanner Bibee (1-2, 5.85 ERA), while the Yankees have opted for Will Warren (1-0, 5.17 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts an equal chance for both the Guardians and Yankees to win today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's NY Yankees-Cleveland game," said Dimers' Chief Content Officer, Nick Slade.

"Based on the latest updates and extensive data, we predict a 50-50 chance for both the Guardians and Yankees, making it a highly competitive matchup."

For further insights into Tuesday's matchup, including best bets and picks, visit our interactive Yankees vs. Guardians predictions page.

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Guardians vs. Yankees Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Tuesday's MLB game between the Yankees and Guardians 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently can't split the two teams, giving both the Yankees and Guardians a 50% chance of winning the game.

According to our model, the Guardians (+1.5) have a 62% chance of covering the run line, while the 8.5-run over/under has a 53% chance of staying under.

Pre-Game Probabilities

Last Updated: 10:32PM, Apr 22

Moneyline

Over / Under

Run Line

Yankees

Win %

51%

49%

+102

-115

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See Matchup

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Guardians

Yankees NYY

+102

Win %

51%

49%

See Matchup

Guardians CLE

-115

Will Warren 1-0, 5.17 ERA

Tanner Bibee 1-2, 5.85 ERA

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Yankees vs. Guardians Odds [4/22/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Yankees vs. Guardians Picks and Best Bets

Our model's biggest edge in today's Yankees vs. Guardians matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Yankees vs. Guardians Game-Day Updates and Essential Details

Tuesday's MLB action between the Guardians and Yankees at Progressive Field is scheduled to commence at 6:10PM ET.

• Who: New York Yankees vs. Cleveland Guardians
• Date: Tuesday, April 22, 2025
• Time: 6:10PM ET/3:10PM PT
• Venue: Progressive Field

Dimers.com's full preview of Tuesday's Yankees vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any NY Yankees vs. Cleveland picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict a close game between the Yankees and Guardians on Tuesday, with each team having a 50% chance of winning.

AI and automation have enhanced this article to quickly deliver accurate Yankees vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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