Twins vs. Cardinals Prediction: Close Contest Projected After New Data Released for MLB Opening Day Matchup [3/27/2025]

The St. Louis Cardinals and Minnesota Twins will lock horns on Opening Day of the 2025 MLB season at Busch Stadium on Thursday, starting at 4:15PM ET.

Sonny Gray (0-0, 0.00 ERA) will be the starting pitcher for the Cardinals, while the Twins will counter with Pablo López (0-0, 0.00 ERA).

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects an equal chance for both the Cardinals and Twins to win today's game.

"Using the latest data, our experts simulated Thursday's Minnesota-St. Louis game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Based on the latest updates and extensive data, we predict a 50-50 chance for both the Cardinals and Twins, making it a highly competitive matchup."

For further insights into Thursday's matchup, including best bets and picks, visit our interactive Twins vs. Cardinals predictions page.

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Twins vs. Twins Prediction: Who Will Win on MLB Opening Day?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Thursday's MLB game between the Twins and Cardinals 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently can't split the two teams, giving both the Twins and Cardinals a 50% chance of winning the game.

According to our model, the Cardinals (+1.5) have a 65% chance of covering the run line, while the over/under total of 7.5 runs has an equal 50-50 chance of hitting.

Pre-Game Probabilities

Last Updated: 7:28PM, Mar 27

Moneyline

Over / Under

Run Line

Twins

Win %

50%

50%

-112

-104

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Cardinals

Twins MIN

-112

Win %

50%

50%

See Matchup

Cardinals STL

-104

Pablo López 0-0, 0.00 ERA

Sonny Gray 0-0, 0.00 ERA

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Twins vs. Cardinals Odds [3/27/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Twins vs. Cardinals Picks and Best Bets

Our model's strongest edge in today's Twins vs. Cardinals matchup is on the over/under.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Twins vs. Cardinals Game-Day Updates and Essential Details

Thursday's MLB game between the Cardinals and Twins at Busch Stadium is scheduled to begin at 4:15PM ET.

• Who: Minnesota Twins vs. St. Louis Cardinals
• Date: Thursday, March 27, 2025
• Time: 4:15PM ET/1:15PM PT
• Venue: Busch Stadium

Dimers.com's full preview of Thursday's Twins vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Minnesota vs. St. Louis picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict a close game between the Twins and Cardinals on Thursday, with each team having a 50% chance of winning.

AI and automation have enhanced this article to quickly deliver accurate Twins vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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