Astros vs. Cardinals Prediction: Houston Predicted to Win Wednesday's MLB Matchup [4/16/2025]

The St. Louis Cardinals and Houston Astros will lock horns in MLB action at Busch Stadium on Wednesday, starting at 1:15PM ET.

The Cardinals will send Steven Matz (0-0, 2.31 ERA) to the mound, pitting him against Ronel Blanco (1-1, 6.94 ERA) for the Astros.

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Astros as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Houston-St. Louis game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Astros' chance of winning at 52%, with the Cardinals at 48%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Astros vs. Cardinals predictions page.

Astros vs. Astros Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Wednesday's MLB matchup between the Astros and Cardinals 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Astros a 52% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 61% chance of covering the run line, while the 8-run over/under has a 53% chance of going over.

Astros vs. Cardinals Odds [4/16/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Astros vs. Cardinals Picks and Best Bets

Our model's strongest edge in today's Astros vs. Cardinals matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

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Astros vs. Cardinals Game-Day Updates and Essential Details

Wednesday's MLB action between the Cardinals and Astros at Busch Stadium is scheduled to start at 1:15PM ET.

• Who: Houston Astros vs. St. Louis Cardinals
• Date: Wednesday, April 16, 2025
• Time: 1:15PM ET/10:15AM PT
• Venue: Busch Stadium

Dimers.com's in-depth preview of Wednesday's Astros vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Houston vs. St. Louis picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Astros, with a 52% win probability, will likely beat the Cardinals on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Astros vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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