Rays vs. Padres Prediction: San Diego Predicted to Win Sunday's MLB Matchup [4/27/2025]

The San Diego Padres and Tampa Bay Rays will lock horns in MLB action at PETCO Park on Sunday, starting at 4:10PM ET.

The Padres will start Randy Vásquez (1-2, 3.97 ERA), while the Rays have opted for Zack Littell (0-5, 5.28 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) projects the Padres as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Tampa Bay-San Diego game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Padres with a win probability of 53%, while the Rays have 47%."

For further insights into Sunday's matchup, including best bets and picks, visit our interactive Rays vs. Padres predictions page.

Get 20% off Dimers Pro With Code 20BASEBALL

Get Dimers Pro

Padres vs. Rays Prediction: Who Will Win?

Using innovative machine learning and data, we have simulated the result of Sunday's MLB matchup between the Rays and Padres 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Padres a 53% chance of defeating the Rays.

According to our model, the over/under total of 8.5 runs has a 57% chance of staying under.

Pre-Game Probabilities

Last Updated: 8:28PM, Apr 27

Moneyline

Over / Under

Rays

Win %

47%

53%

-113

+105

Get the best bets with Dimers Pro

See Matchup

Get Dimers Pro

Padres

Rays TB

-113

Win %

47%

53%

See Matchup

Padres SD

+105

Zack Littell 0-5, 5.28 ERA

Randy Vásquez 1-2, 3.97 ERA

Get the best bets with Dimers Pro

Get Dimers Pro

Rays vs. Padres Odds [4/27/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Rays vs. Padres Picks and Best Bets

Our model's strongest edge in today's Rays vs. Padres matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Unlock Every Rays-Padres Pick

Get Dimers Pro

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Rays vs. Padres Game-Day Updates and Essential Details

Sunday's MLB action between the Padres and Rays at PETCO Park is scheduled to begin at 4:10PM ET.

• Who: Tampa Bay Rays vs. San Diego Padres
• Date: Sunday, April 27, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: PETCO Park

Dimers.com's in-depth preview of Sunday's Rays vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Tampa Bay vs. San Diego picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Padres, with a 53% win probability, will likely beat the Rays on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Rays vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most up-to-date predictions for the World Series, American League, National League and each division.