Astros vs. Twins Prediction: Minnesota Predicted to Win Sunday's MLB Matchup [4/6/2025]

The Minnesota Twins and Houston Astros are scheduled to meet in MLB action at Target Field on Sunday, starting at 2:10PM ET.

Chris Paddack (0-1, 24.30 ERA) will start on the mound for the Twins, up against Ronel Blanco (0-1, 5.40 ERA) for the Astros.

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects the Twins as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Houston-Minnesota game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Twins with a win probability of 51%, while the Astros have 49%."

For a closer look at Sunday's matchup, including best bets and picks, visit our interactive Astros vs. Twins predictions page.

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Astros vs. Astros Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the result of Sunday's MLB game between the Astros and Twins 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Twins a 51% chance of beating the Astros.

According to our model, the Astros (+1.5) have a 66% chance of covering the run line, while the over/under total of 8.5 runs has a 52% chance of going over.

Pre-Game Probabilities

Last Updated: 6:27PM, Apr 6

Moneyline

Over / Under

Run Line

Astros

Win %

48%

52%

-102

+102

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See Matchup

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Twins

Astros HOU

-102

Win %

48%

52%

See Matchup

Twins MIN

+102

Ronel Blanco 0-1, 5.40 ERA

Chris Paddack 0-1, 24.30 ERA

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Astros vs. Twins Odds [4/6/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Astros vs. Twins Picks and Best Bets

Our model's biggest edge in today's Astros vs. Twins matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Astros vs. Twins Game-Day Updates and Essential Details

Sunday's MLB action between the Twins and Astros at Target Field is scheduled to commence at 2:10PM ET.

• Who: Houston Astros vs. Minnesota Twins
• Date: Sunday, April 6, 2025
• Time: 2:10PM ET/11:10AM PT
• Venue: Target Field

Dimers.com's comprehensive preview of Sunday's Astros vs. Twins matchup includes our prediction, picks and the latest betting odds.

Before making any Houston vs. Minnesota picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Twins, with a 51% win probability, will likely beat the Astros on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Astros vs. Twins insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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