Free MLB Picks Today: Wednesday's MLB Best Bets Include Angels vs. Athletics Play [5/21/2025]

Another action-packed MLB slate is on deck for 5/21, and we've crunched the numbers to bring you the sharpest MLB best bets today along with our top free MLB picks for today.

Today's MLB best bets include matchups like the Angels vs. Athletics game at 10:05PM ET, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge MLB bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Wednesday, May 21, 2025, including our complete set of MLB picks and best bets.

List of MLB Best Bets Tonight [5/21, Updated 10:02PM ET]

After diving deep into the numbers and running thousands of simulations, our leading predictive analytics model has figured out the best baseball bet for Wednesday, May 21, 2025.

This is the only free pick available right now. Our full set of MLB predictions is exclusive to Dimers Pro.

Angels vs. Athletics Under 10.5 Runs (-118)

• Probability: 56.3%
• Edge: 2.2%
• Matchup: Angels vs. Athletics (10:05PM ET, Wednesday)

Our model has pinpointed a high-probability MLB betting opportunity tonight, which comes in the Angels vs. Athletics game. We recommend an over/under bet on Under 10.5 Runs at -118 odds, with our analysis showing a 56.3% chance of hitting and a compelling edge of 2.2%.

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Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for May 21, 2025.

List of Upcoming MLB Games to Bet On [5/21/2025]

• Angels vs. Athletics (10:05PM ET, Wednesday)
• D-Backs vs. Dodgers (10:10PM ET, Wednesday)
• Rangers vs. Yankees (12:35PM ET, Thursday)
• Padres vs. Blue Jays (1:07PM ET, Thursday)
• Phillies vs. Rockies (3:10PM ET, Thursday)
• Angels vs. Athletics (3:35PM ET, Thursday)
• Guardians vs. Tigers (6:40PM ET, Thursday)
• Braves vs. Nationals (6:45PM ET, Thursday)
• Orioles vs. Red Sox (6:45PM ET, Thursday)
• Mariners vs. Astros (8:10PM ET, Thursday)

More About MLB

The best on this page form part of our MLB player props and MLB best bets series.

For more MLB betting content, we have MLB trends for every game, as well as daily MLB betting news and the latest World Series odds and predictions.

Conclusion

Our MLB best bets are locked and loaded for May 21, 2025, featuring plays such as Under 10.5 Runs. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate MLB insights quickly, with human oversight ensuring high editorial quality. Our predictions are grounded in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.