Creighton vs. Louisville Prediction: Louisville Predicted to Win March Madness First Round Matchup [3/20/2025]

Louisville and Creighton will lock horns in March Madness First Round action at Rupp Arena on Thursday, starting at 12:15PM ET.

Based on updated simulations, Dimers' proven college basketball model (see Dimers Pro for full access) projects Louisville as the most likely winner of today's game.

Check the latest March Madness bracket projections and 2025 NCAA Championship probabilities from our expert team.

"Using the latest data, our experts simulated Thursday's Creighton-Louisville game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast Louisville with a win probability of 59% and Creighton with 41%."

For further insights into Thursday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Creighton vs. Louisville predictions page.

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Creighton vs. Louisville Prediction: Who Will Win and Advance to the Second Round?

Using trusted machine learning and data, we have simulated the outcome of Thursday's NCAA Tournament game between Creighton and Louisville 10,000 times as part of our March Madness predictions coverage.

Our independent predictive model currently gives Louisville a 59% chance of beating Creighton. Our predicted final score has Louisville winning 74-72.

According to our model, Creighton (+3.5) has a 56% chance of covering the spread, while the over/under total of 146.5 points has a 53% chance of going over.

Pre-Game Probabilities

Last Updated: 3:33PM, Mar 20

Spread

Over / Under

Moneyline

Creighton

Creighton +3.5

56%

44%

-113

-105

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Louisville

Creighton CREI

-113

Creighton +3.5

56%

44%

See Matchup

Louisville LOU

-105

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Creighton vs. Louisville March Madness Odds

We have researched the best March Madness odds in America for this First Round game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Boost your betting this month with the top March Madness betting sites and March Madness betting promos, sourced from top sportsbooks and DFS operators.

Creighton vs. Louisville Picks and Best Bets

Our model's strongest edge in today's Creighton vs. Louisville matchup is on the total.

Our expert predictions, aligned with the best odds, reveal the best March Madness picks and March Madness best bets for every game throughout the tournament.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Creighton vs. Louisville Game-Day Updates and Essential Details

Thursday's college basketball matchup between Louisville and Creighton at Rupp Arena is scheduled to start at 12:15PM ET.

• Who: Creighton vs. Louisville
• Date: Thursday, March 20, 2025
• Time: 12:15PM ET/9:15AM PT
• Venue: Rupp Arena
• March Madness Stage: First Round

Dimers.com's comprehensive preview of Thursday's Creighton vs. Louisville matchup includes our prediction, picks and the latest betting odds.

Before making any Creighton vs. Louisville picks, be sure to check out the latest March Madness predictions and betting advice from Dimers Pro.

Key March Madness Guides and Insights

• Learn about NCAA Championship history and the lowest-seeded team to ever win March Madness
• Get answers to legal questions, including which states you can legally bet on college sports and the minimum age required to place a bet on March Madness
• A breakdown of March Madness futures bets and popular prop bets for the NCAA tournament
• Explore strategy with guides on identifying value bets during the tournament and betting on individual player awards like Tournament MVP
• Understand the tournament format, including how many games are played in March Madness and how venue locations impact teams when playing at neutral sites

Conclusion

We predict Louisville, with a 59% win probability, will likely beat Creighton on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Creighton vs. Louisville insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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More on College Basketball

Keep up with the latest college basketball predictions, college basketball betting news and NCAA Tournament parlay picks throughout the tournament. Plus, our NCAA Tournament Championship odds provide the most up-to-date predictions for every March Madness contender.