Guardians vs. Padres Prediction: San Diego Predicted to Win Tuesday's MLB Matchup [4/1/2025]

The San Diego Padres will face the Cleveland Guardians in MLB action at PETCO Park on Tuesday, starting at 9:40PM ET.

Michael King (0-0, 10.12 ERA) will start for the Padres, while the Guardians have opted for Logan Allen (0-0, 0.00 ERA).

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Padres as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's Cleveland-San Diego game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Padres with a win probability of 60%, compared to 40% for the Guardians."

For further insights into Tuesday's matchup, including best bets and picks, visit our interactive Guardians vs. Padres predictions page.

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Guardians vs. Guardians Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data analysis, we have simulated the result of Tuesday's MLB game between the Guardians and Padres 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Padres a 60% chance of beating the Guardians.

According to our model, the Guardians (+1.5) have a 58% chance of covering the run line, while the over/under total of 7.5 runs has an equal 50-50 chance of hitting.

Pre-Game Probabilities

Last Updated: 1:28AM, Apr 2

Moneyline

Over / Under

Run Line

Guardians

Win %

39%

61%

+150

-167

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Padres

Guardians CLE

+150

Win %

39%

61%

See Matchup

Padres SD

-167

Logan Allen 0-0, 0.00 ERA

Michael King 0-0, 10.13 ERA

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Guardians vs. Padres Odds [4/1/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Guardians vs. Padres Picks and Best Bets

Our model's strongest edge in today's Guardians vs. Padres matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Guardians vs. Padres Game-Day Updates and Essential Details

Tuesday's MLB game between the Padres and Guardians at PETCO Park is scheduled to commence at 9:40PM ET.

• Who: Cleveland Guardians vs. San Diego Padres
• Date: Tuesday, April 1, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers.com's full preview of Tuesday's Guardians vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Cleveland vs. San Diego picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 60% win probability, will likely beat the Guardians on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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