White Sox vs. Tigers Prediction: Detroit Predicted to Win Friday's MLB Matchup [4/4/2025]

The Detroit Tigers and Chicago whitesox will meet in MLB action at Comerica Park on Friday, starting at 1:10PM ET.

The Tigers will have Jack Flaherty (0-0, 3.18 ERA) as their starting pitcher, while the White Sox are going with Jonathan Cannon (0-0, 0.00 ERA).

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Tigers as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's CHI White Sox-Detroit game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Tigers' chance of winning is 66%, while the White Sox' is 34%."

For a closer look at Friday's matchup, including best bets and picks, visit our interactive White Sox vs. Tigers predictions page.

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White Sox vs. White Sox Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data analysis, we have simulated the result of Friday's MLB game between the White Sox and Tigers 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Tigers a 66% chance of defeating the White Sox.

According to our model, the White Sox (+1.5) have a 55% chance of covering the run line, while the over/under total of 7 runs has a 51% chance of going over.

Pre-Game Probabilities

Last Updated: 4:28PM, Apr 4

Moneyline

Over / Under

Run Line

White Sox

Win %

34%

66%

+220

-235

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Tigers

White Sox CWS

+220

Win %

34%

66%

See Matchup

Tigers DET

-235

Jonathan Cannon 0-0, 0.00 ERA

Jack Flaherty 0-0, 3.18 ERA

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White Sox vs. Tigers Odds [4/4/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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White Sox vs. Tigers Picks and Best Bets

Our model's biggest edge in today's White Sox vs. Tigers matchup is on the over/under.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

White Sox vs. Tigers Game-Day Updates and Essential Details

Friday's MLB matchup between the Tigers and White Sox at Comerica Park is scheduled to commence at 1:10PM ET.

• Who: Chicago White Sox vs. Detroit Tigers
• Date: Friday, April 4, 2025
• Time: 1:10PM ET/10:10AM PT
• Venue: Comerica Park

Dimers.com's in-depth preview of Friday's White Sox vs. Tigers matchup includes our prediction, picks and the latest betting odds.

Before making any CHI White Sox vs. Detroit picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Tigers, with a 66% win probability, will likely beat the White Sox on Friday.

AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Tigers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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