Cubs vs. Diamondbacks Prediction: Arizona Predicted to Win MLB Opening Day Matchup [3/27/2025]

MLB Opening Day action continues on Thursday at 10:10PM ET as the Chicago Cubs take on the Arizona Diamondbacks at Chase Field.

Zac Gallen (0-0, 0.00 ERA) will be the starting pitcher for the Diamondbacks, while the Cubs will counter with Justin Steele (0-1, 11.25 ERA).

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Diamondbacks as the most likely winner of today's game.

"Using the latest data, our experts simulated Thursday's CHI Cubs-Arizona game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast the Diamondbacks with a win probability of 54% and the Cubs with 46%."

For further insights into Thursday's matchup, including best bets and picks, visit our interactive Cubs vs. Diamondbacks predictions page.

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Cubs vs. Cubs Prediction: Who Will Win on MLB Opening Day?

Using trusted machine learning and data, we have simulated the result of Thursday's MLB game between the Cubs and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Diamondbacks a 54% chance of defeating the Cubs.

According to our model, the Cubs (+1.5) have a 64% chance of covering the run line, while the 8.5-run over/under has a 51% chance of staying under.

Pre-Game Probabilities

Last Updated: 2:28AM, Mar 28

Moneyline

Over / Under

Run Line

Cubs

Win %

47%

53%

+108

-122

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See Matchup

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D-Backs

Cubs CHC

+108

Win %

47%

53%

See Matchup

D-Backs ARI

-122

Justin Steele 0-1, 11.25 ERA

Zac Gallen 0-0, 0.00 ERA

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Cubs vs. Diamondbacks Odds [3/27/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Diamondbacks Picks and Best Bets

Our model's biggest edge in today's Cubs vs. Diamondbacks matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Cubs vs. Diamondbacks Game-Day Updates and Essential Details

Thursday's MLB game between the Diamondbacks and Cubs at Chase Field is scheduled to commence at 10:10PM ET.

• Who: Chicago Cubs vs. Arizona Diamondbacks
• Date: Thursday, March 27, 2025
• Time: 10:10PM ET/7:10PM PT
• Venue: Chase Field

Dimers.com's full preview of Thursday's Cubs vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any CHI Cubs vs. Arizona picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Diamondbacks, with a 54% win probability, will likely beat the Cubs on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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