Cubs vs. Diamondbacks Prediction: Arizona Predicted to Win Friday's MLB Matchup [3/28/2025]

The Arizona Diamondbacks will take on the Chicago Cubs in MLB action at Chase Field on Friday, beginning at 9:40PM ET.

The Diamondbacks will send Merrill Kelly (0-0, 0.00 ERA) to the mound, while the Cubs are going with Jameson Taillon (0-0, 0.00 ERA).

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Diamondbacks as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's CHI Cubs-Arizona game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Diamondbacks' chance of winning is 58%, while the Cubs' is 42%."

For further insights into Friday's matchup, including best bets and picks, visit our interactive Cubs vs. Diamondbacks predictions page.

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Cubs vs. Cubs Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and statistical analysis, we have simulated the result of Friday's MLB game between the Cubs and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Diamondbacks a 58% chance of defeating the Cubs.

According to our model, the Cubs (+1.5) have a 60% chance of covering the run line, while the over/under total of 9 runs has a 52% chance of going over.

Pre-Game Probabilities

Last Updated: 1:28AM, Mar 29

Moneyline

Over / Under

Run Line

Cubs

Win %

42%

58%

+128

-142

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D-Backs

Cubs CHC

+128

Win %

42%

58%

See Matchup

D-Backs ARI

-142

Jameson Taillon 0-0, 0.00 ERA

Merrill Kelly 0-0, 0.00 ERA

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Cubs vs. Diamondbacks Odds [3/28/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Cubs vs. Diamondbacks Picks and Best Bets

Our model's biggest edge in today's Cubs vs. Diamondbacks matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Cubs vs. Diamondbacks Game-Day Updates and Essential Details

Friday's MLB action between the Diamondbacks and Cubs at Chase Field is scheduled to commence at 9:40PM ET.

• Who: Chicago Cubs vs. Arizona Diamondbacks
• Date: Friday, March 28, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: Chase Field

Dimers.com's comprehensive preview of Friday's Cubs vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any CHI Cubs vs. Arizona picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Diamondbacks, with a 58% win probability, will likely beat the Cubs on Friday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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