Cardinals vs. Bills Prediction: Buffalo Predicted to Win Following Latest Data Analysis for NFL Week 1 [2024]

The Buffalo Bills will face the Arizona Cardinals in NFL Week 1 action at Highmark Stadium on Sunday, beginning at 1:00PM ET.

Based on the latest simulation results, Dimers' advanced NFL model (see Dimers Pro for full access) predicts the Bills as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Cardinals-Bills game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Bills with a win probability of 71%, while the Cardinals have 29%."

Cardinals vs. Bills Game-Day Updates and Essential Details

The NFL Week 1 matchup between the Bills and Cardinals at Highmark Stadium is scheduled to begin at 1:00PM ET.

• Who: Arizona Cardinals vs. Buffalo Bills
• Date: Sunday, September 8, 2024
• Time: 1:00PM ET/10:00AM PT
• Venue: Highmark Stadium
• Tickets: Get tickets for the game on Ticketmaster
• Merchandise: Buy Bills and Cardinals gear at Fanatics
• Live Stream: Watch this game on CBS via Hulu, FuboTV or Paramount+

Dimers.com's in-depth preview of Sunday's Cardinals vs. Bills matchup includes our prediction, picks and the latest betting odds.

Before making any Bills vs. Cardinals picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

Cardinals vs. Bills Predictions

Using trusted machine learning and data, we have simulated the outcome of Sunday's NFL game between the Cardinals and Bills 10,000 times as part of our NFL predictions coverage.

Our famous predictive model gives the Bills a 71% chance of defeating the Cardinals in Week 1 of the NFL season. Our predicted final score has the Bills winning 25-19.

According to our model, the Cardinals (+6.5) have a 57% chance of covering the spread, while the over/under total of 45.5 points has a 51% chance of going over.

Cardinals vs. Bills Odds

We have sourced the best betting odds in America for this game, which are listed here:

Bet Type	Cardinals	Bills
Spread	+6.5 (-105)	-6.5 (-114)
Moneyline	+260	-300
Total	o45.5 (-112)	u45.5 (-108)

All odds are correct at the time of publication and are subject to change.

Cardinals vs. Bills Picks

Our model's strongest edge in today's Cardinals vs. Bills matchup is on the total.

Our expert predictions, matched against the best odds, reveal the best NFL picks for every game throughout the season.

Unlimited access to our picks, including this one, is available via Dimers Pro.

Cardinals vs. Bills TD Scorers

Who will score the first touchdown in Cardinals vs. Bills?

According to our model, Buffalo's Josh Allen is most likely to score the first TD in Cardinals vs. Bills.

Our projections give Allen an 11.6% chance of scoring the first TD at Highmark Stadium, while the Bills QB is a 47.1% chance of scoring an anytime touchdown.

First Touchdown Scorer Predictions

Arizona Cardinals

Player	First TD Probability
James Conner	8.9%
Marvin Harrison	6.7%
Kyler Murray	5.5%

Buffalo Bills

Player	First TD Probability
Josh Allen	11.6%
James Cook	8.0%
Dalton Kincaid	5.9%

Anytime Touchdown Scorer Predictions

Arizona Cardinals

Player	Anytime TD Probability
James Conner	39.7%
Marvin Harrison	30.9%
Kyler Murray	26.1%

Buffalo Bills

Player	Anytime TD Probability
Josh Allen	47.1%
James Cook	35.0%
Dalton Kincaid	27.2%

For a complete analysis of the most likely first and anytime TD scorers this week, see our NFL Week 1 touchdown scorer predictions

Cardinals vs Bills Player Props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Cardinals and Bills. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Cardinals-Bills page now to access every player prop projection.

Cardinals vs. Bills Quarterbacks

Of the starting quarterbacks, the Cardinals' Kyler Murray is projected to throw for fewer yards than the Bills' Josh Allen.

Cardinals Rushing

James Conner, Kyler Murray and Trey Benson are projected to be the leading rushers for the Cardinals.

Player	Position
James Conner	RB
Kyler Murray	QB
Trey Benson	RB

Bills Rushing

James Cook, Josh Allen and Ray Davis are expected to lead the Bills in rushing yards.

Player	Position
James Cook	RB
Josh Allen	QB
Ray Davis	RB

Cardinals Receiving

Trey McBride, Marvin Harrison, Greg Dortch, Michael Wilson and Chris Moore are projected to top the receiving yards for the Cardinals.

Player	Position
Trey McBride	TE
Marvin Harrison	WR
Greg Dortch	WR
Michael Wilson	WR
Chris Moore	WR

Bills Receiving

Khalil Shakir, Dalton Kincaid, Keon Coleman, Curtis Samuel and James Cook are projected to lead the Bills in receiving yards.

Player	Position
Khalil Shakir	WR
Dalton Kincaid	TE
Keon Coleman	WR
Curtis Samuel	WR
James Cook	RB

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Conclusion

We predict the Bills, with a 71% win probability, will likely beat the Cardinals on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Bills insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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