Yankees vs. Orioles Prediction and Odds - May 18, 2022

The Baltimore Orioles face the favored New York Yankees at Oriole Park at Camden Yards on Wednesday, commencing at 7:05PM ET.

The Orioles will send Jordan Lyles (2-3, 4.38 ERA) to the mound, while the Yankees are going with Gerrit Cole (3-0, 2.94 ERA).

Dimers' top betting picks for Yankees vs. Orioles, plus game predictions and best odds, are detailed in this article.

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Who will win Yankees vs. Orioles?

Using trusted machine learning and data, Dimers.com has simulated Wednesday's Yankees-Orioles MLB game 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, currently gives the Yankees a 67% chance of winning against the Orioles .

More: Yankees vs. Orioles Simulated 10K Times

Yankees vs. Orioles Odds

• Run Line: Orioles +1.5 (+130), Yankees -1.5 (-144)
• Moneyline: Orioles +230, Yankees -260
• Total: Over/Under 7.5 (+105/-120)

Run Line, Moneyline and Over/Under

The Orioles are currently +1.5 underdogs against the Yankees, with +130 at DraftKings Sportsbook the best odds currently available.

For the favored Yankees (-1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on the market at -144.

BetMGM currently has the best moneyline odds for the Orioles at +230, which means you can bet $100 to profit $230, earning a total payout of $330, if they win.

Elsewhere, DraftKings Sportsbook currently has the best moneyline odds for the Yankees at -260, where you can risk $260 to win $100, for a total payout of $360, if they come out on top.

The Over/Under sits at 7.5 with DraftKings Sportsbook, which currently has the best odds for the Over at +105, while FanDuel Sportsbook currently has the best odds for the Under at -120.

As always, check out the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Yankees (-1.5) are a 55% chance of covering the run line, while the Over/Under total of 7.5 runs is a 51% chance of going Over.

More: Free Prop Picks

Best Bets for Yankees vs. Orioles

• Run Line: Orioles +1.5 @ +130 via DraftKings Sportsbook (1.5% edge)
• Moneyline: Orioles @ +230 via BetMGM (3.0% edge)
• Total: Over 7.5 @ +105 via DraftKings Sportsbook (51% probability)

Dimers' best bets are based on world-class simulations and betting intelligence to help you make smarter decisions with the legal sportsbooks in the USA.

Even though the Yankees are more likely to cover the run line, our best bet of Orioles +1.5 is based on the expectation of that happening, according to DimersBOT, and the top odds available.

And while the Yankees are more likely to win the game, according to DimersBOT, betting on the Orioles moneyline is the best option because of the 3.0% edge found when comparing our data-led probabilities to the sportsbooks' odds currently available.

Taking advantage of the edges published on Dimers is one of the keys to being a profitable bettor in the long run.

Yankees vs. Orioles Probabilities

Use our widget below to see up-to-date Moneyline, Over/Under and Run Line probabilities and odds for NY Yankees vs. Baltimore, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Wednesday's Yankees-Orioles matchup, including pregame predictions, free betting picks, and live scores.

Don't forget, DimersBOT updates regularly, so refresh this page for the latest betting analysis before Yankees vs. Orioles on Wednesday May 18, 2022.

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Risk-Free Bet for Yankees vs. Orioles

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Yankees vs. Orioles 2022 Game Info

Wednesday's matchup between the Orioles and Yankees at Oriole Park at Camden Yards is scheduled to start at 7:05PM ET.

• Date: Wednesday May 18, 2022
• Time: 7:05PM ET / 4:05PM PT
• Venue: Oriole Park at Camden Yards

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Want more MLB predictions like this?

To get more MLB betting predictions like you've just read for Yankees vs. Orioles, all you've gotta do is visit our MLB Betting News section. It's that easy – they're all there!

We use the power of predictive analytics to find value in the markets so we can publish the most comprehensive MLB betting previews out there. We do this by comparing our in-house probabilities against the sportsbooks' odds (aka Vegas odds) the minute they go live.

So, get ahead of the game and beat the bookies today – it's only a click away.

Lastly, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds to win the World Series.