White Sox vs. Twins Prediction and Odds - Sep 28, 2022

The Minnesota Twins square off with the Chicago White Sox in MLB action at Target Field on Wednesday, starting at 7:40PM ET.

The Twins will send Josh Winder (4-5, 4.20 ERA) to the mound, up against Johnny Cueto (7-9, 3.15 ERA) for the White Sox.

Dimers' best betting picks for White Sox vs. Twins, plus game predictions and betting odds, are featured in this article.

Who will win White Sox vs. Twins?

Based on high-tech computer power and data, Dimers.com has simulated Wednesday's White Sox-Twins MLB game 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, gives the White Sox a 51% chance of defeating the Twins.

More: Free Betting Guide for White Sox vs. Twins

White Sox vs. Twins Current Odds

• Run Line: Twins +1.5 (-175), White Sox -1.5 (+158)
• Moneyline: Twins -110, White Sox -106
• Total: Over/Under 7.5 (-110/-105)

Run Line, Moneyline and Over/Under

The Twins are listed as +1.5 underdogs versus the White Sox, with -175 at DraftKings Sportsbook the best odds currently available.

For the favored White Sox (-1.5) to cover the run line, Caesars Sportsbook has the best odds currently on offer at +158.

In a sign of how close this game is expected to be, both the Twins and White Sox are currently at minus-money betting odds on the moneyline.

Caesars Sportsbook currently has the best moneyline odds for the Twins at -110. That means you can risk $110 to win $100, for a total payout of $210, if they get the W.

Meanwhile, FanDuel Sportsbook currently has the best moneyline odds for the White Sox at -106, where you can risk $106 to win $100, for a total payout of $206, if they come out on top.

The Over/Under sits at 7.5 with Caesars Sportsbook, which currently has the best odds for the Over at -110, while BetMGM currently has the best odds for the Under at -105.

As always, check out the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Twins (+1.5) are a 62% chance of covering the run line, while the Over/Under total of 7.5 runs is a 61% chance of going Over.

More: Track Your Bets via Bet Center

Best Bets for White Sox vs. Twins

• Run Line: Twins +1.5 @ -175 via DraftKings Sportsbook (62% probability)
• Moneyline: White Sox @ -106 via FanDuel Sportsbook (51% probability)
• Total: Over 7.5 @ -110 via Caesars Sportsbook (61% probability) 🔥

If you see a 🔥, that means it's one of our best free picks of the day across all sports.

Dimers' best bets are based on world-class modeling and betting expertise to bring you the best possible plays 24/7.

White Sox vs. Twins Prediction

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Dimers has full betting coverage of Wednesday's White Sox-Twins matchup, including pregame predictions, free betting picks, and live win probabilities.

Don't forget, DimersBOT updates often, so keep an eye on this page for any changes to our betting insights before White Sox vs. Twins on Wednesday September 28, 2022.

White Sox vs. Twins 2022 Game Info

Wednesday's action between the Twins and White Sox at Target Field is scheduled to begin at 7:40PM ET.

• Who: Chicago White Sox vs. Minnesota Twins
• Date: Wednesday September 28, 2022
• Time: 7:40PM ET / 4:40PM PT
• Venue: Target Field

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Finally, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds to win the World Series.