White Sox vs. Guardians Prediction and Odds - Sep 15, 2022

The Cleveland Guardians and Chicago White Sox are scheduled to meet in MLB at Progressive Field on Thursday, starting at 1:10PM ET.

Hunter Gaddis (0-1, 21.60 ERA) will start on the mound for the Guardians, pitting him against Lance Lynn (6-5, 4.07 ERA) for the White Sox.

Dimers' top betting picks for White Sox vs. Guardians, as well as game predictions and best odds, are detailed below.

Who will win White Sox vs. Guardians?

Using trusted computer power and data, Dimers.com has simulated Thursday's White Sox-Guardians MLB matchup 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, gives the White Sox a 55% chance of defeating the Guardians.

More: White Sox vs. Guardians Simulated 10K Times

White Sox vs. Guardians Game Odds

• Run Line: Guardians +1.5 (-130), White Sox -1.5 (+115)
• Moneyline: Guardians +130, White Sox -145
• Total: Over/Under 7.5 (-105/-110)

Run Line, Moneyline and Over/Under

The Guardians are listed as +1.5 underdogs versus the White Sox, with -130 at Caesars Sportsbook the best odds currently available.

For the favored White Sox (-1.5) to cover the run line, BetMGM has the best odds currently on offer at +115.

Caesars Sportsbook currently has the best moneyline odds for the Guardians at +130. That means you can bet $100 to profit $130, earning a total payout of $230, if they win.

Elsewhere, DraftKings Sportsbook currently has the best moneyline odds for the White Sox at -145, where you can risk $145 to win $100, for a total payout of $245, if they come out on top.

The Over/Under is set at 7.5 with BetMGM, which currently has the best odds for the Over at -105, while Caesars Sportsbook currently has the best odds for the Under at -110.

As always, make sure you check all of the sportsbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 57% chance of covering the run line, while the Over/Under total of 7.5 runs is a 57% chance of going Over.

More: Best Bets for Every MLB Game

Best Bets for White Sox vs. Guardians

• Run Line: Guardians +1.5 @ -130 via Caesars Sportsbook (57% probability)
• Moneyline: Guardians @ +130 via Caesars Sportsbook (1.3% edge)
• Total: Over 7.5 @ -105 via BetMGM (57% probability) 🔥

Every time you see a 🔥, that means you've found one of our best bets today across all sports.

Dimers' best bets are based on world-class modeling and betting expertise to help you make better investments with the legal sportsbooks in your state.

While the White Sox are more likely to win the game, according to DimersBOT, betting on the Guardians moneyline is the best option due to the 1.3% edge found when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges published here at Dimers is one of the keys to being profitable in the long run.

White Sox vs. Guardians Prediction

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Dimers has full betting coverage of Thursday's White Sox-Guardians matchup, including pregame predictions, top betting picks, and live win probabilities.

Remember, DimersBOT updates regularly, so keep checking this article for any changes to our betting insights before White Sox vs. Guardians on Thursday September 15, 2022.

White Sox vs. Guardians 2022 Game Info

Thursday's matchup between the Guardians and White Sox at Progressive Field is scheduled to start at 1:10PM ET.

• Who: Chicago White Sox vs. Cleveland Guardians
• Date: Thursday September 15, 2022
• Time: 1:10PM ET / 10:10AM PT
• Venue: Progressive Field

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What other MLB games are on today?

The White Sox and Guardians aren't the only two MLB teams you can bet on. DimersBOT never stops and we've got picks and top bets for each and every MLB game in our MLB Bet Hub page.

Not only do we provide with you quality predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Check it out now!

Lastly, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities paired with the best odds available.