White Sox vs. Guardians Prediction and Odds - Aug 21, 2022

MLB action continues on Sunday at 12:05PM ET as the Chicago White Sox square off with the Cleveland Guardians at Progressive Field.

The Guardians will have Aaron Civale (2-5, 5.62 ERA) start, while the White Sox will counter with Dylan Cease (12-5, 2.09 ERA).

Dimers' free betting picks for White Sox vs. Guardians, plus game predictions and best odds, are detailed below.

Who will win White Sox vs. Guardians?

Using cutting-edge machine learning and data, Dimers.com has simulated Sunday's White Sox-Guardians MLB matchup 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, gives the White Sox a 52% chance of beating the Guardians.

More: White Sox vs. Guardians Simulated 10K Times

White Sox vs. Guardians Current Odds

• Run Line: Guardians +1.5 (-160), White Sox -1.5 (+145)
• Moneyline: Guardians +105, White Sox -120
• Total: Over/Under 7.5 (+100/-105)

Run Line, Moneyline and Over/Under

The Guardians are +1.5 underdogs against the White Sox, with -160 at BetMGM the best odds currently available.

For the favored White Sox (-1.5) to cover the run line, PointsBet has the best odds currently on offer at +145.

BetMGM currently has the best moneyline odds for the Guardians at +105. That means you can bet $100 to profit $105, earning a total payout of $205, if they win.

Meanwhile, FanDuel Sportsbook currently has the best moneyline odds for the White Sox at -120, where you can risk $120 to win $100, for a total payout of $220, if they come out on top.

The Over/Under for total runs scored sits at 7.5 with PointsBet, which currently has the best odds for the Over at +100, while Caesars Sportsbook currently has the best odds for the Under at -105.

As always, make sure you check the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 62% chance of covering the run line, while the 7.5-run Over/Under is a 53% chance of going Over.

More: Best Prop Bets to Make Today

Best Bets for White Sox vs. Guardians

• Run Line: Guardians +1.5 @ -160 via BetMGM (62% probability)
• Moneyline: Guardians @ +105 via BetMGM
• Total: Over 7.5 @ +100 via PointsBet (53% probability)

Dimers' best bets are based on complex simulations and wagering expertise to bring you the best possible plays every day of the year.

While the White Sox are more likely to win the game, according to DimersBOT, taking the Guardians moneyline is the best option because of the edge found when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges seen on Dimers.com is crucial to being profitable in the long run.

White Sox vs. Guardians Prediction

Use our dynamic widget below to see up-to-date Moneyline, Over/Under and Run Line probabilities and odds for CHI White Sox vs. Cleveland, and click or tap on See Matchup for more.

Dimers has full coverage of Sunday's White Sox-Guardians matchup, including pregame predictions, free betting picks, and live win probabilities.

Remember, DimersBOT updates regularly, so check this article for the latest betting insights before White Sox vs. Guardians on Sunday August 21, 2022.

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Note: When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may get a referral fee.

White Sox vs. Guardians 2022 Game Info

Sunday's action between the Guardians and White Sox at Progressive Field is scheduled to start at 12:05PM ET.

• Who: Cleveland Guardians vs. Chicago White Sox
• Date: Sunday August 21, 2022
• Time: 12:05PM ET / 9:05AM PT
• Venue: Progressive Field

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What other MLB games are on today?

The White Sox and Guardians aren't the only two MLB teams you can bet on. DimersBOT never stops and we've got picks and best bets for each and every MLB matchup in our MLB Bet Hub section.

Not only do we provide with you first-class predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Check it out today!

While you're here, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds to win the World Series.