Nationals vs. Pirates Prediction: Tight Battle Projected in Updated Analysis for Wednesday's MLB Matchup [4/16/2025]

MLB action continues on Wednesday at 6:40PM ET as the Washington Nationals take on the Pittsburgh Pirates at PNC Park.

The Pirates will have Bailey Falter (0-2, 7.20 ERA) as their starting pitcher, while the Nationals will counter with Mitchell Parker (2-0, 1.96 ERA).

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts an equal chance for both the Pirates and Nationals to win today's game.

"Our team has simulated the outcome of Wednesday's Washington-Pittsburgh game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Based on the latest updates and extensive data, we predict a 50-50 chance for both the Pirates and Nationals, making it a highly competitive matchup."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Nationals vs. Pirates predictions page.

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Nationals vs. Nationals Prediction: Who Will Win?

Using trusted machine learning and data, we have simulated the result of Wednesday's MLB matchup between the Nationals and Pirates 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently can't split the two teams, giving both the Nationals and Pirates a 50% chance of winning the game.

According to our model, the 8.5-run over/under has a 55% chance of staying under.

Pre-Game Probabilities

Last Updated: 10:28PM, Apr 16

Moneyline

Over / Under

Run Line

Nationals

Win %

50%

50%

+102

-112

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See Matchup

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Pirates

Nationals WSH

+102

Win %

50%

50%

See Matchup

Pirates PIT

-112

Mitchell Parker 2-0, 1.96 ERA

Bailey Falter 0-2, 7.20 ERA

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Nationals vs. Pirates Odds [4/16/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Nationals vs. Pirates Picks and Best Bets

Our model's strongest edge in today's Nationals vs. Pirates matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Nationals vs. Pirates Game-Day Updates and Essential Details

Wednesday's MLB action between the Pirates and Nationals at PNC Park is scheduled to commence at 6:40PM ET.

• Who: Washington Nationals vs. Pittsburgh Pirates
• Date: Wednesday, April 16, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: PNC Park

Dimers.com's comprehensive preview of Wednesday's Nationals vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any Washington vs. Pittsburgh picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict a close game between the Nationals and Pirates on Wednesday, with each team having a 50% chance of winning.

AI and automation have enhanced this article to quickly deliver accurate Nationals vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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