Wake Forest vs. Clemson CFB Predictions and Odds - Nov 20, 2021

Clemson hosts Wake Forest in College Football Week 12 action at Memorial Stadium on Saturday, beginning at 12:00 PM EST.

Dimers' free betting picks for Wake Forest vs. Clemson, as well as our score prediction and best odds, are featured in this article.

Who will win Wake Forest vs. Clemson?

Using state-of-the-art machine learning and data, Dimers.com has simulated Saturday's Wake Forest-Clemson NCAA Football game 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, gives Clemson a 58% chance of defeating Wake Forest.

MORE: Wake Forest vs. Clemson simulated 10,000 times

Wake Forest vs. Clemson Point Spread, Moneyline and Over/Under

Clemson is the -3.5 favorite against Wake Forest, with -110 at Caesars Sportsbook the best odds available.

For the underdog Wake Forest (+3.5) to cover the spread, Caesars Sportsbook also has the best odds on offer at -110.

FanDuel Sportsbook has the best moneyline odds for Clemson at -164, which means you can risk $164 to win $100, for a total payout of $264, if it gets the W.

Meanwhile, DraftKings Sportsbook has the best moneyline odds for Wake Forest at +150, where you can put down $100 to profit $150, earning a total payout of $250, if it wins.

The Over/Under for total points scored is set at 58.5 with FanDuel Sportsbook, which has the best odds for the Over at -106, as well as the best odds for the Under at -114.

As always, make sure you check all the legal sportbooks that are available in your state for the best College Football odds and lines.

According to DimersBOT, the bookmakers have got it right and both Wake Forest and Clemson are a 50% chance of covering the spread, while the 58.5-point Over/Under is a 53% chance of going Under.

MORE: Best bets today for all major pro and college sports

Best Bets for Wake Forest vs. Clemson

• Spread: Wake Forest +3.5 at -110 with Caesars Sportsbook (50% probability)
• Moneyline: Wake Forest Win at +150 with DraftKings Sportsbook (2.1% edge)
• Over/Under: Under 58.5 at -114 with FanDuel Sportsbook (53% probability)

While Clemson is more likely to win the game, according to DimersBOT, betting on Wake Forest moneyline is the best option due to the 2.1% edge found when comparing our data-led probabilities to the sportsbooks' odds.

Taking advantage of the edges published here at Dimers.com is pivotal to achieving long-term profitability as a bettor.

Wake Forest vs. Clemson Score Prediction

Dimers.com's predicted final score for Wake Forest vs. Clemson at Memorial Stadium on Saturday has Clemson winning 30-27.

Dimers has full coverage of this week's Wake Forest-Clemson game, including pre-game predictions, top betting picks, and live updates.

Remember, DimersBOT updates frequently, so refresh this page for any changes before Wake Forest vs. Clemson on Saturday November 20, 2021.

Wake Forest vs. Clemson 2021 CFB Game Info

When does Clemson play Wake Forest in College Football?

• Date: Saturday November 20, 2021
• Time: 12:00 PM EST / 9:00 AM PST
• Venue: Memorial Stadium

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