Vanderbilt vs. Saint Mary's Prediction: Saint Mary's Predicted to Win March Madness First Round Matchup [3/21/2025]

March Madness action continues on Friday at 3:15PM ET as Vanderbilt locks horns with Saint Mary's in college basketball action at Rocket Arena.

Based on the latest simulation results, Dimers' proven college basketball model (see Dimers Pro for full access) projects Saint Mary's as the most likely winner of today's game.

Check the latest March Madness bracket projections and 2025 NCAA Championship probabilities from our expert team.

"Employing the latest data, our experts simulated Friday's Vanderbilt-Saint Mary's game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict Saint Mary's' chance of winning is 68%, while Vanderbilt's is 32%."

For a closer look at Friday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Vanderbilt vs. Saint Mary's predictions page.

EXCLUSIVE OFFER: Sign up to Dimers Pro with code MARCH today to enjoy a full month for the price of just one week!

Vanderbilt vs. Saint Mary's Prediction: Who Will Win and Advance to the Second Round?

Using innovative machine learning and data, we have simulated the outcome of Friday's NCAA Tournament game between Vanderbilt and Saint Mary's 10,000 times as part of our March Madness predictions coverage.

Our independent predictive model currently gives Saint Mary's a 68% chance of defeating Vanderbilt. Our predicted final score has Saint Mary's winning 71-66.

According to our model, the bookmakers have got it right, and Vanderbilt and Saint Mary's each have a 50% chance of covering the spread, while the 136.5-point over/under has a 53% chance of going over.

Vanderbilt vs. Saint Mary's March Madness Odds

We have sourced the best March Madness odds in America for this First Round game, which are listed here:

Bet Type	Vanderbilt	Saint Mary's
Spread	+4.5 (-105)	-4.5 (-112)
Moneyline	+170	-198
Total	o136.5 (-110)	u136.5 (-110)

All odds are correct at the time of publication and are subject to change.

Boost your betting this month with the top March Madness betting sites and March Madness betting promos, sourced from top sportsbooks and DFS operators.

Vanderbilt vs. Saint Mary's Picks and Best Bets

Our model's biggest edge in today's Vanderbilt vs. Saint Mary's matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best March Madness picks and March Madness best bets for every game throughout the tournament.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Vanderbilt vs. Saint Mary's Game-Day Updates and Essential Details

Friday's college basketball action between Saint Mary's and Vanderbilt at Rocket Arena is scheduled to commence at 3:15PM ET.

• Who: Vanderbilt vs. Saint Mary's
• Date: Friday, March 21, 2025
• Time: 3:15PM ET/12:15PM PT
• Venue: Rocket Arena
• March Madness Stage: First Round

Dimers.com's comprehensive preview of Friday's Vanderbilt vs. Saint Mary's matchup includes our prediction, picks and the latest betting odds.

Before making any Vanderbilt vs. Saint Mary's picks, be sure to check out the latest March Madness predictions and betting advice from Dimers Pro.

Key March Madness Guides and Insights

• Learn about NCAA Championship history and the lowest-seeded team to ever win March Madness
• Get answers to legal questions, including which states you can legally bet on college sports and the minimum age required to place a bet on March Madness
• A breakdown of March Madness futures bets and popular prop bets for the NCAA tournament
• Explore strategy with guides on identifying value bets during the tournament and betting on individual player awards like Tournament MVP
• Understand the tournament format, including how many games are played in March Madness and how venue locations impact teams when playing at neutral sites

Conclusion

We predict Saint Mary's, with a 68% win probability, will likely beat Vanderbilt on Friday.

AI and automation have enhanced this article to quickly deliver accurate Vanderbilt vs. Saint Mary's insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on College Basketball

Stay up-to-date with the latest college basketball predictions, college basketball betting news and NCAA Tournament parlay picks throughout the tournament. Plus, our NCAA Tournament Championship odds provide the most up-to-date predictions for every March Madness contender.