Twins vs. Guardians Prediction and Odds - Sep 19, 2022

MLB action continues on Monday at 1:10PM ET as the Minnesota Twins square off with the Cleveland Guardians at Progressive Field.

Cal Quantrill (12-5, 3.51 ERA) will be on the bump for the Guardians, while the Twins are going with Sonny Gray (8-4, 2.83 ERA).

Dimers' best betting picks for Twins vs. Guardians, as well as game predictions and betting odds, are featured below.

Who will win Twins vs. Guardians?

Using state-of-the-art computer power and data, Dimers.com has simulated Monday's Twins-Guardians MLB matchup 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, gives the Guardians a 51% chance of winning against the Twins.

More: Twins vs. Guardians Simulated 10K Times

Twins vs. Guardians Odds

• Run Line: Guardians +1.5 (-195), Twins -1.5 (+172)
• Moneyline: Guardians -120, Twins +105
• Total: Over/Under 7 (-105/-112)

Run Line, Moneyline and Over/Under

The Guardians are +1.5 underdogs against the Twins, with -195 at DraftKings Sportsbook the best odds currently available.

For the favored Twins (-1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at +172.

BetMGM currently has the best moneyline odds for the Guardians at -120, which means you can risk $120 to win $100, for a total payout of $220, if they get the W.

Meanwhile, Caesars Sportsbook currently has the best moneyline odds for the Twins at +105, where you can bet $100 to profit $105, earning a total payout of $205, if they win.

The Over/Under is set at 7 with BetMGM, which currently has the best odds for the Over at -105, while FanDuel Sportsbook currently has the best odds for the Under at -112.

As always, make sure you check all of the online sportsbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 65% chance of covering the run line, while the Over/Under total of 7 runs is a 57% chance of going Over.

More: Free Prop Picks

Best Bets for Twins vs. Guardians

• Run Line: Twins -1.5 @ +172 via FanDuel Sportsbook
• Moneyline: Twins @ +105 via Caesars Sportsbook (0.3% edge)
• Total: Over 7 @ -105 via BetMGM (57% probability) 🔥

When you see a 🔥, you know it's one of Dimers' best bets today across all major pro and college sports.

Our best bets are based on world-class simulations and wagering expertise to help you make better investments with your state's legal sportsbooks.

Although the Guardians are more likely to cover the run line, our best bet of Twins -1.5 is based on the expectation of that happening, according to DimersBOT, and the top odds available.

And while the Guardians are more likely to win the game, according to DimersBOT, taking the Twins moneyline is the best option because of the edge identified when comparing our data-led probabilities to the sportsbooks' odds currently available.

Taking advantage of the edges seen on Dimers.com is one of the keys to achieving long-term profitability.

Twins vs. Guardians Prediction

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Dimers has full betting coverage of Monday's Twins-Guardians matchup, including pregame predictions, top betting picks, and live win probabilities.

Don't forget, DimersBOT updates frequently, so keep an eye on this page for the latest betting analysis ahead of Twins vs. Guardians on Monday September 19, 2022.

Twins vs. Guardians 2022 Game Info

Monday's game between the Guardians and Twins at Progressive Field is scheduled to start at 1:10PM ET.

• Who: Minnesota Twins vs. Cleveland Guardians
• Date: Monday September 19, 2022
• Time: 1:10PM ET / 10:10AM PT
• Venue: Progressive Field

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What other MLB games are on today?

Now you've got the 411 on Twins vs. Guardians, get the latest betting coverage for all upcoming MLB games in our MLB Bet Hub, where you can find probabilities and odds, as well as our best bets for every single MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Finally, Dimers' Baseball Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities paired with the best odds to win the World Series.