Twins vs. Guardians Prediction and Odds - May 5, 2023

The Cleveland Guardians square off with the Minnesota Twins in MLB action at Progressive Field on Friday, beginning at 7:10PM ET.

The Guardians will send Peyton Battenfield (0-2, 4.67 ERA) to the mound, pitting him against Bailey Ober (1-0, 1.59 ERA) for the Twins.

Dimers' best betting picks for Twins vs. Guardians, as well as game predictions and betting odds, are featured below.

Who Will Win: Twins vs. Guardians

Using cutting-edge machine learning and data, Dimers.com has simulated Friday's Twins-Guardians MLB game 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, currently gives the Twins a 53% chance of beating the Guardians.

More: Betting Analysis for Twins vs. Guardians

Twins vs. Guardians Current Odds

• Run Line: Guardians +1.5 (-154), Twins -1.5 (+140)
• Moneyline: Guardians +106, Twins -120
• Total: Over/Under 8.5 (-115/-102)

Run Line, Moneyline and Over/Under

The Guardians are listed as +1.5 underdogs versus the Twins, with -154 at FanDuel Sportsbook the best odds currently available.

For the favored Twins (-1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on the market at +140.

FanDuel Sportsbook currently has the best moneyline odds for the Guardians at +106, which means you can throw down $100 to profit $106, earning a total payout of $206, if they win.

Meanwhile, DraftKings Sportsbook currently has the best moneyline odds for the Twins at -120, where you can risk $120 to win $100, for a total payout of $220, if they come out on top.

The Over/Under is set at 8.5 with PointsBet, which currently has the best odds for the Over at -115, while FanDuel Sportsbook currently has the best odds for the Under at -102.

As always, check out the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) have a 59% chance of covering the run line, while the 8.5-run Over/Under has a 55% chance of going Over.

More: Live Scores for All Major Sports

Best Bets for Twins vs. Guardians

• Run Line: Twins -1.5 @ +140 via DraftKings Sportsbook
• Moneyline: Guardians @ +106 via FanDuel Sportsbook
• Total: Over 8.5 @ -115 via PointsBet (55% probability)

Dimers' best bets are based on complex simulations and wagering expertise to bring you the best possible plays 24/7/365.

Although the Guardians are more likely to cover the run line, our best bet of Twins -1.5 is based on the expectation of that happening, according to DimersBOT, and the best odds available.

And while the Twins are more likely to win the game, according to DimersBOT, betting on the Guardians moneyline is the best option due to the edge found when comparing our data-led probabilities to the sportsbooks' odds currently available.

Taking advantage of the edges seen here at Dimers.com is crucial to achieving long-term profitability as a bettor.

Twins vs. Guardians Prediction

Click or tap on See Matchup for more.

Dimers has full betting coverage of Friday's Twins-Guardians matchup, including pregame predictions, free picks, and live win probabilities.

Don't forget, DimersBOT updates often, so keep checking this article for the latest betting analysis before Twins vs. Guardians on Friday May 5, 2023.

Twins vs. Guardians 2023 Game Info

Friday's game between the Guardians and Twins at Progressive Field is scheduled to start at 7:10PM ET.

• Who: Minnesota Twins vs. Cleveland Guardians
• Date: Friday May 5, 2023
• Time: 7:10PM ET / 4:10PM PT
• Venue: Progressive Field

Enjoy Dimers and want to keep the site free? Every time you register and bet with a sportsbook featured here, we get paid a small fee.

These fees help us keep Dimers free for sports fans like you. So, if you like what you see, support us by joining one of our legal sports betting partners.

Calling Our Shot ⚾️ Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Make Smarter Sports Betting Decisions with Dimers

Our picks are based on 10,000 simulations per game, using reliable and up-to-date data sources and analytical methods.

While these Twins vs. Guardians predictions can help you make informed decisions, it's important that you only bet what you can afford to lose and manage your bankroll effectively.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Want More MLB Predictions Like This?

So, you liked our Twins vs. Guardians betting analysis? Awesome. Did you know our MLB Betting News page has a comprehensive betting preview for every MLB game as soon as the sportsbooks put out their odds?

That's right, our predictive analytics model then compares those odds (aka Vegas odds) against its own probabilities to find edges in the markets. This allows us to write the most authoritative MLB betting previews and get the jump on the public and the sportsbooks.

In addition to MLB picks and predictions, we also provide the best MLB prop bets for today, projecting home runs, RBIs, and more against the best odds available every single day of the MLB season.

While you're here, Dimers' Baseball Futures page is our in-house approach to revealing who will win the World Series, with our data-led probabilities paired with the best odds available.