Blue Jays vs. Astros Prediction: Houston Predicted to Win Wednesday's MLB Matchup [4/23/2025]

MLB action continues on Wednesday at 7:40PM ET as the Toronto Blue Jays take on the Houston Astros at Daikin Park.

The Astros will start Ryan Gusto (2-1, 3.18 ERA), up against Bowden Francis (2-2, 3.13 ERA) for the Blue Jays.

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Astros as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Toronto-Houston game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Astros' chance of winning at 52%, with the Blue Jays at 48%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Blue Jays vs. Astros predictions page.

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Astros vs. Blue Jays Prediction: Who Will Win?

Using powerful machine learning and data, we have simulated the outcome of Wednesday's MLB matchup between the Blue Jays and Astros 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Astros a 52% chance of defeating the Blue Jays.

According to our model, the over/under total of 8 runs has a 55% chance of going over.

Pre-Game Probabilities

Last Updated: 11:28PM, Apr 23

Moneyline

Over / Under

Run Line

Blue Jays

Win %

48%

52%

-102

-110

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See Matchup

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Astros

Blue Jays TOR

-102

Win %

48%

52%

See Matchup

Astros HOU

-110

Bowden Francis 2-2, 3.13 ERA

Ryan Gusto 2-1, 3.18 ERA

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Blue Jays vs. Astros Odds [4/23/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Blue Jays vs. Astros Picks and Best Bets

Our model's biggest edge in today's Blue Jays vs. Astros matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Blue Jays vs. Astros Game-Day Updates and Essential Details

Wednesday's MLB game between the Astros and Blue Jays at Daikin Park is scheduled to start at 7:40PM ET.

• Who: Toronto Blue Jays vs. Houston Astros
• Date: Wednesday, April 23, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Daikin Park

Dimers.com's in-depth preview of Wednesday's Blue Jays vs. Astros matchup includes our prediction, picks and the latest betting odds.

Before making any Toronto vs. Houston picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Astros, with a 52% win probability, will likely beat the Blue Jays on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Blue Jays vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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