Blue Jays vs. Astros Prediction: Houston Predicted to Win Monday's MLB Matchup [4/21/2025]

MLB action continues on Monday at 8:10PM ET as the Toronto Blue Jays lock horns with the Houston Astros at Daikin Park.

Hunter Brown (2-1, 1.50 ERA) will get the ball for the Astros, up against Kevin Gausman (2-1, 2.49 ERA) for the Blue Jays.

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Astros as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's Toronto-Houston game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Astros are likely to win, with a probability of 58%, compared to the Blue Jays' 42%."

For a closer look at Monday's matchup, including best bets and picks, visit our interactive Blue Jays vs. Astros predictions page.

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Blue Jays vs. Blue Jays Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Monday's MLB matchup between the Blue Jays and Astros 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Astros a 58% chance of defeating the Blue Jays.

According to our model, the Blue Jays (+1.5) have a 62% chance of covering the run line, while the over/under total of 7.5 runs has a 52% chance of going over.

Pre-Game Probabilities

Last Updated: 12:29AM, Apr 22

Moneyline

Over / Under

Run Line

Blue Jays

Win %

42%

58%

+120

-136

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Astros

Blue Jays TOR

+120

Win %

42%

58%

See Matchup

Astros HOU

-136

Kevin Gausman 2-1, 2.49 ERA

Hunter Brown 2-1, 1.50 ERA

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Blue Jays vs. Astros Odds [4/21/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Blue Jays vs. Astros Picks and Best Bets

Our model's strongest edge in today's Blue Jays vs. Astros matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Blue Jays vs. Astros Game-Day Updates and Essential Details

Monday's MLB action between the Astros and Blue Jays at Daikin Park is scheduled to start at 8:10PM ET.

• Who: Toronto Blue Jays vs. Houston Astros
• Date: Monday, April 21, 2025
• Time: 8:10PM ET/5:10PM PT
• Venue: Daikin Park

Dimers.com's in-depth preview of Monday's Blue Jays vs. Astros matchup includes our prediction, picks and the latest betting odds.

Before making any Toronto vs. Houston picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Astros, with a 58% win probability, will likely beat the Blue Jays on Monday.

AI and automation have enhanced this article to quickly deliver accurate Blue Jays vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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