Tigers vs. White Sox Prediction and Odds - Sep 25, 2022

The Chicago White Sox take on the Detroit Tigers in MLB action at Guaranteed Rate Field on Sunday, beginning at 2:10PM ET.

Dylan Cease (14-7, 2.13 ERA) will get the ball for the White Sox, up against Tyler Alexander (4-10, 4.91 ERA) for the Tigers.

Dimers' best betting picks for Tigers vs. White Sox, plus game predictions and betting odds, are detailed below.

Who will win Tigers vs. White Sox?

Using state-of-the-art computer power and data, Dimers.com has simulated Sunday's Tigers-White Sox MLB game 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, gives the White Sox a 69% chance of winning against the Tigers.

More: Full Betting Guide for Tigers vs. White Sox

Tigers vs. White Sox Current Odds

• Run Line: White Sox -1.5 (-111), Tigers +1.5 (-105)
• Moneyline: White Sox -230, Tigers +196
• Total: Over/Under 8 (-105/-105)

Run Line, Moneyline and Over/Under

The White Sox are listed as -1.5 favorites versus the Tigers, with -111 at FanDuel Sportsbook the best odds currently available.

For the underdog Tigers (+1.5) to cover the run line, BetMGM has the best odds currently on offer at -105.

DraftKings Sportsbook currently has the best moneyline odds for the White Sox at -230. That means you can risk $230 to win $100, for a total payout of $330, if they get the W.

Meanwhile, Caesars Sportsbook currently has the best moneyline odds for the Tigers at +196, where you can bet $100 to profit $196, earning a total payout of $296, if they win.

The Over/Under sits at 8 with Caesars Sportsbook, which currently has the best odds for the Over at -105, while BetMGM currently has the best odds for the Under at -105.

As always, check out all of the online sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the White Sox (-1.5) are a 52% chance of covering the run line, while the 8-run Over/Under is a 54% chance of going Over.

More: Best Free Bet Tracker

Best Bets for Tigers vs. White Sox

• Run Line: White Sox -1.5 @ -111 via FanDuel Sportsbook (52% probability)
• Moneyline: White Sox @ -230 via DraftKings Sportsbook (69% probability)
• Total: Over 8 @ -105 via Caesars Sportsbook (54% probability)

Our best bets are based on complex modeling and wagering expertise to help you make better decisions with your state's legal sportsbooks.

Tigers vs. White Sox Prediction

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Dimers has full betting coverage of Sunday's Tigers-White Sox matchup, including pregame predictions, computer picks, and live win probabilities.

Don't forget, DimersBOT updates often, so check this article for any changes to our betting insights before Tigers vs. White Sox on Sunday September 25, 2022.

Tigers vs. White Sox 2022 Game Info

Sunday's action between the White Sox and Tigers at Guaranteed Rate Field is scheduled to begin at 2:10PM ET.

• Who: Detroit Tigers vs. Chicago White Sox
• Date: Sunday September 25, 2022
• Time: 2:10PM ET / 11:10AM PT
• Venue: Guaranteed Rate Field

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What MLB games are on today?

Now you've got the 411 on Tigers vs. White Sox, get the latest betting analysis for all upcoming MLB games in Dimers' MLB Bet Hub, where you can find probabilities and odds, and our best bets for every single MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Lastly, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities paired with the best odds to win the World Series.