Tigers vs. Orioles Prediction and Odds - Sep 21, 2022

The Baltimore Orioles take on the Detroit Tigers in MLB action at Oriole Park at Camden Yards on Wednesday, commencing at 7:05PM ET.

The Orioles will send Jordan Lyles (10-11, 4.70 ERA) to the mound, pitting him against Matt Manning (2-2, 3.28 ERA) for the Tigers.

Dimers' best betting picks for Tigers vs. Orioles, plus game predictions and best odds, are featured in this article.

Who will win Tigers vs. Orioles?

Using trusted machine learning and data, Dimers.com has simulated Wednesday's Tigers-Orioles MLB matchup 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, gives the Orioles a 60% chance of defeating the Tigers.

More: Tigers vs. Orioles Simulated 10K Times

Tigers vs. Orioles Odds

• Run Line: Orioles -1.5 (+135), Tigers +1.5 (-155)
• Moneyline: Orioles -150, Tigers +130
• Total: Over/Under 8 (-120/+100)

Run Line, Moneyline and Over/Under

The Orioles are currently -1.5 favorites against the Tigers, with +135 at BetMGM the best odds currently available.

For the underdog Tigers (+1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on the market at -155.

BetMGM currently has the best moneyline odds for the Orioles at -150. That means you can risk $150 to win $100, for a total payout of $250, if they get the W.

On the other hand, DraftKings Sportsbook currently has the best moneyline odds for the Tigers at +130, where you can bet $100 to profit $130, earning a total payout of $230, if they win.

The Over/Under sits at 8 with Caesars Sportsbook, which currently has the best odds for the Over at -120, as well as the best odds for the Under at +100.

As always, check out all the sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Tigers (+1.5) are a 57% chance of covering the run line, while the Over/Under total of 8 runs is a 55% chance of going Over.

More: Free Online Bet Tracking Tool

Best Bets for Tigers vs. Orioles

• Run Line: Orioles -1.5 @ +135 via BetMGM (0.1% edge)
• Moneyline: Orioles @ -150 via BetMGM (60% probability)
• Total: Over 8 @ -120 via Caesars Sportsbook (55% probability)

Our best bets are based on complex simulations and gambling intelligence to help you make better decisions with the legal sportsbooks in America.

Even though the Tigers are more likely to cover the run line, our best bet of Orioles -1.5 is based on the likelihood of that happening, according to DimersBOT, and the top odds available.

Tigers vs. Orioles Prediction

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Dimers has full betting coverage of Wednesday's Tigers-Orioles matchup, including pregame predictions, free picks, and live win probabilities.

Don't forget, DimersBOT updates often, so refresh this page for any changes to our betting analysis before Tigers vs. Orioles on Wednesday September 21, 2022.

Tigers vs. Orioles 2022 Game Info

Wednesday's action between the Orioles and Tigers at Oriole Park at Camden Yards is scheduled to commence at 7:05PM ET.

• Who: Detroit Tigers vs. Baltimore Orioles
• Date: Wednesday September 21, 2022
• Time: 7:05PM ET / 4:05PM PT
• Venue: Oriole Park at Camden Yards

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What other MLB games are on today?

Now you've got the 411 on Tigers vs. Orioles, take a look at the latest betting coverage for all upcoming MLB games in Dimers' MLB Bet Hub. There you can find probabilities and odds, and our best bets for every single MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Lastly, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds on the market.