Rays vs. Padres Prediction: San Diego Predicted to Win Saturday's MLB Matchup [4/26/2025]

MLB action continues on Saturday at 8:40PM ET as the Tampa Bay Rays take on the San Diego Padres at PETCO Park.

Dylan Cease (1-1, 6.04 ERA) will start for the Padres, up against Ryan Pepiot (1-3, 4.82 ERA) for the Rays.

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) projects the Padres as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's Tampa Bay-San Diego game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Padres are more likely to win, while the Rays have a lower chance of victory."

For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Rays vs. Padres predictions page.

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Padres vs. Rays Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the outcome of Saturday's MLB matchup between the Rays and Padres 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Padres a 59% chance of beating the Rays.

According to our model, the Rays (+1.5) have a 61% chance of covering the run line, while the 7-run over/under has an equal 50-50 chance of hitting.

Pre-Game Probabilities

Last Updated: 12:27AM, Apr 27

Moneyline

Over / Under

Run Line

Rays

Win %

41%

59%

+138

-150

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Padres

Rays TB

+138

Win %

41%

59%

See Matchup

Padres SD

-150

Ryan Pepiot 1-3, 4.82 ERA

Dylan Cease 1-1, 6.04 ERA

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Rays vs. Padres Odds [4/26/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Rays vs. Padres Picks and Best Bets

Our model's strongest edge in today's Rays vs. Padres matchup is on the over/under.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free MLB Picks

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Rays vs. Padres Game-Day Updates and Essential Details

Saturday's MLB game between the Padres and Rays at PETCO Park is scheduled to start at 8:40PM ET.

• Who: Tampa Bay Rays vs. San Diego Padres
• Date: Saturday, April 26, 2025
• Time: 8:40PM ET/5:40PM PT
• Venue: PETCO Park

Dimers.com's in-depth preview of Saturday's Rays vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Tampa Bay vs. San Diego picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Padres, with a 59% win probability, will likely beat the Rays on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Rays vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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