Rays vs. Padres Prediction: San Diego Predicted to Win Friday's MLB Matchup [4/25/2025]

The San Diego Padres will take on the Tampa Bay Rays in MLB action at PETCO Park on Friday, beginning at 9:40PM ET.

Michael King (3-0, 2.57 ERA) will be on the bump for the Padres, pitting him against Shane Baz (2-0, 3.22 ERA) for the Rays.

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Padres as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Tampa Bay-San Diego game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Padres' chance of winning is 58%, while the Rays' is 42%."

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Rays vs. Padres predictions page.

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Padres vs. Rays Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the result of Friday's MLB game between the Rays and Padres 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Padres a 58% chance of beating the Rays.

According to our model, the Rays (+1.5) have a 63% chance of covering the run line, while the over/under total of 7 runs has an equal 50-50 chance of hitting.

Pre-Game Probabilities

Last Updated: 1:28AM, Apr 26

Moneyline

Over / Under

Run Line

Rays

Win %

42%

58%

+125

-141

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Padres

Rays TB

+125

Win %

42%

58%

See Matchup

Padres SD

-141

Shane Baz 2-0, 3.22 ERA

Michael King 3-0, 2.57 ERA

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Rays vs. Padres Odds [4/25/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Rays vs. Padres Picks and Best Bets

Our model's strongest edge in today's Rays vs. Padres matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Rays vs. Padres Game-Day Updates and Essential Details

Friday's MLB action between the Padres and Rays at PETCO Park is scheduled to begin at 9:40PM ET.

• Who: Tampa Bay Rays vs. San Diego Padres
• Date: Friday, April 25, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers.com's in-depth preview of Friday's Rays vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Tampa Bay vs. San Diego picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Padres, with a 58% win probability, will likely beat the Rays on Friday.

AI and automation have enhanced this article to quickly deliver accurate Rays vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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