Syracuse vs. Louisville CFB Predictions and Odds - Nov 13, 2021

College Football Week 11 action continues on Saturday at 12:00 PM EST as Syracuse takes on Louisville at Cardinal Stadium.

Dimers' best betting picks for Syracuse vs. Louisville, as well as game predictions and best odds, are featured in this article.

Who will win Syracuse vs. Louisville?

Based on high-tech machine learning and data, Dimers.com has simulated Saturday's Syracuse-Louisville NCAA Football matchup 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, gives Louisville a 58% chance of defeating Syracuse.

MORE: Syracuse vs. Louisville simulated 10,000 times

Syracuse vs. Louisville Point Spread, Moneyline and Over/Under

Louisville is currently the -3 favorite at home to Syracuse, with -115 at Caesars Sportsbook the best odds available.

For the underdog Syracuse (+3) to cover the spread, PointsBet has the best odds on offer at +100.

DraftKings Sportsbook has the best moneyline odds for Louisville at -155. That means you can risk $155 to win $100, for a total payout of $255, if it gets the W.

Elsewhere, PointsBet has the best moneyline odds for Syracuse at +140, where you can put down $100 to profit $140, earning a total payout of $240, if it wins.

The Over/Under sits at 56.5 with FanDuel Sportsbook, which has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, check out all the sportsbooks available in your state for the best College Football odds and lines.

According to DimersBOT, Louisville (-3) is a 51% chance of covering the spread, while the Over/Under total of 56.5 points is a 54% chance of going Under.

Best Bets for Syracuse vs. Louisville

• Spread: Syracuse +3 at +100 with PointsBet
• Moneyline: Syracuse Win at +140 with PointsBet (0.4% edge)
• Over/Under: Under 56.5 at -110 with FanDuel Sportsbook (54% probability)

Even though Louisville is more likely to cover the spread, our best bet of Syracuse +3 is based on the likelihood of that happening, according to DimersBOT, and the top odds available.

And while Louisville is more likely to win the game, according to DimersBOT, taking Syracuse moneyline is the best option due to the 0.4% edge found when comparing our data-led probabilities to the sportsbooks' odds.

Taking advantage of the edges seen here at Dimers is pivotal to achieving long-term profitability as a bettor.

MORE: Predictions and best bets for every College Football game

Syracuse vs. Louisville Score Prediction

Dimers.com's predicted final score for Syracuse vs. Louisville at Cardinal Stadium this Saturday has Louisville winning 30-26.

Dimers has full betting coverage of this week's Syracuse-Louisville game, including pre-game predictions, free picks, and live win probabilities.

Remember, DimersBOT updates regularly, so keep checking this page for any changes ahead of Syracuse vs. Louisville on Saturday November 13, 2021.

Syracuse vs. Louisville 2021 CFB Game Info

When does Louisville play Syracuse in College Football?

• Date: Saturday November 13, 2021
• Time: 12:00 PM EST / 9:00 AM PST
• Venue: Cardinal Stadium

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Want more College Football previews like this?

To get more College Football betting previews like this one for Syracuse vs. Louisville, all you've gotta do is visit Dimers' College Football Betting News section. It's that easy – they're all there!

We use the power of predictive analytics to find value in the markets so we can produce the best CFB betting previews out there. We're able to do this by comparing our unique and accurate probabilities against the sportsbooks' odds (aka Vegas odds) the minute they go live.

So, get ahead of the game and beat the 'books today – it's only a click away.