Cardinals vs. Pirates Prediction: St. Louis Predicted to Win Wednesday's MLB Matchup [4/9/2025]

The Pittsburgh Pirates and St. Louis Cardinals are scheduled to meet in MLB action at PNC Park on Wednesday, starting at 12:35PM ET.

The Pirates will have Mitch Keller (1-1, 7.45 ERA) as their starting pitcher, while the Cardinals have opted for Erick Fedde (1-1, 7.00 ERA).

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Cardinals as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's St. Louis-Pittsburgh game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Cardinals' chance of winning at 51%, with the Pirates at 49%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Cardinals vs. Pirates predictions page.

Get 20% off Dimers Pro With Code 20BASEBALL

Get Dimers Pro

Cardinals vs. Cardinals Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Wednesday's MLB matchup between the Cardinals and Pirates 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Cardinals a 51% chance of beating the Pirates.

According to our model, the Pirates (+1.5) have a 62% chance of covering the run line, while the over/under total of 7.5 runs has a 53% chance of going over.

Pre-Game Probabilities

Last Updated: 4:28PM, Apr 9

Moneyline

Over / Under

Run Line

Cardinals

Win %

51%

49%

-110

-102

Get the best bets with Dimers Pro

See Matchup

Get Dimers Pro

Pirates

Cardinals STL

-110

Win %

51%

49%

See Matchup

Pirates PIT

-102

Erick Fedde 1-1, 7.00 ERA

Mitch Keller 1-1, 7.45 ERA

Get the best bets with Dimers Pro

Get Dimers Pro

Cardinals vs. Pirates Odds [4/9/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Cardinals vs. Pirates Picks and Best Bets

Our model's biggest edge in today's Cardinals vs. Pirates matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Unlock Every Cardinals-Pirates Pick

Get Dimers Pro

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Cardinals vs. Pirates Game-Day Updates and Essential Details

Wednesday's MLB game between the Pirates and Cardinals at PNC Park is scheduled to start at 12:35PM ET.

• Who: St. Louis Cardinals vs. Pittsburgh Pirates
• Date: Wednesday, April 9, 2025
• Time: 12:35PM ET/9:35AM PT
• Venue: PNC Park

Dimers.com's comprehensive preview of Wednesday's Cardinals vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any St. Louis vs. Pittsburgh picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Cardinals, with a 51% win probability, will likely beat the Pirates on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the most up-to-date predictions for the World Series, American League, National League and each division.