Cardinals vs. Pirates Prediction: Pittsburgh Predicted to Win Tuesday's MLB Matchup [4/8/2025]

The Pittsburgh Pirates and St. Louis Cardinals are scheduled to meet in MLB action at PNC Park on Tuesday, starting at 6:40PM ET.

Paul Skenes (1-0, 1.46 ERA) will start on the mound for the Pirates, while the Cardinals are going with Sonny Gray (1-0, 5.73 ERA).

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects the Pirates as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's St. Louis-Pittsburgh game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Pirates with a win probability of 57%, compared to 43% for the Cardinals."

For further insights into Tuesday's matchup, including best bets and picks, visit our interactive Cardinals vs. Pirates predictions page.

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Cardinals vs. Cardinals Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and statistical analysis, we have simulated the result of Tuesday's MLB game between the Cardinals and Pirates 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Pirates a 57% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 63% chance of covering the run line, while the 6-run over/under has a 57% chance of going over.

Pre-Game Probabilities

Last Updated: 10:28PM, Apr 8

Moneyline

Over / Under

Run Line

Cardinals

Win %

43%

57%

+120

-137

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Pirates

Cardinals STL

+120

Win %

43%

57%

See Matchup

Pirates PIT

-137

Sonny Gray 1-0, 5.73 ERA

Paul Skenes 1-0, 1.46 ERA

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Cardinals vs. Pirates Odds [4/8/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Pirates Picks and Best Bets

Our model's biggest edge in today's Cardinals vs. Pirates matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Cardinals vs. Pirates Game-Day Updates and Essential Details

Tuesday's MLB game between the Pirates and Cardinals at PNC Park is scheduled to commence at 6:40PM ET.

• Who: St. Louis Cardinals vs. Pittsburgh Pirates
• Date: Tuesday, April 8, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: PNC Park

Dimers.com's in-depth preview of Tuesday's Cardinals vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any St. Louis vs. Pittsburgh picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Pirates, with a 57% win probability, will likely beat the Cardinals on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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