Cardinals vs. Pirates Prediction: St. Louis Predicted to Win Monday's MLB Matchup [4/7/2025]

MLB action continues on Monday at 6:40PM ET as the St. Louis Cardinals square off with the Pittsburgh Pirates at PNC Park.

The Pirates will send Carmen Mlodzinski (0-1, 9.82 ERA) to the mound, up against Matthew Liberatore (0-0, 4.50 ERA) for the Cardinals.

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Cardinals as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's St. Louis-Pittsburgh game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Cardinals are likely to win, with a probability of 53%, compared to the Pirates' 47%."

For further insights into Monday's matchup, including best bets and picks, visit our interactive Cardinals vs. Pirates predictions page.

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Cardinals vs. Cardinals Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the outcome of Monday's MLB matchup between the Cardinals and Pirates 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Cardinals a 53% chance of defeating the Pirates.

According to our model, the Pirates (+1.5) have a 60% chance of covering the run line, while the 8.5-run over/under has a 55% chance of staying under.

Pre-Game Probabilities

Last Updated: 10:28PM, Apr 7

Moneyline

Over / Under

Run Line

Cardinals

Win %

53%

47%

-110

+100

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Pirates

Cardinals STL

-110

Win %

53%

47%

See Matchup

Pirates PIT

+100

Matthew Liberatore 0-0, 4.50 ERA

Carmen Mlodzinski 0-1, 9.82 ERA

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Cardinals vs. Pirates Odds [4/7/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Cardinals vs. Pirates Picks and Best Bets

Our model's biggest edge in today's Cardinals vs. Pirates matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Cardinals vs. Pirates Game-Day Updates and Essential Details

Monday's MLB matchup between the Pirates and Cardinals at PNC Park is scheduled to begin at 6:40PM ET.

• Who: St. Louis Cardinals vs. Pittsburgh Pirates
• Date: Monday, April 7, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: PNC Park

Dimers.com's full preview of Monday's Cardinals vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any St. Louis vs. Pittsburgh picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Cardinals, with a 53% win probability, will likely beat the Pirates on Monday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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