Southern Illinois vs. Northwestern CFB Prediction and Odds - Sep 17, 2022

Northwestern takes on Southern Illinois in College Football action at Ryan Field on Saturday, starting at 12:00PM ET.

Dimers' free betting picks for Southern Illinois vs. Northwestern, plus game predictions and best odds, are featured below.

Today's Southern Illinois vs. Northwestern betting preview is proudly sponsored by DraftKings Sportsbook, which has an outstanding Bet $5, Win $200 promo for new customers.

Who will win Southern Illinois vs. Northwestern?

Using cutting-edge computer power and data, Dimers.com has simulated Southern Illinois vs. Northwestern 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, currently gives Northwestern an 81% chance of defeating Southern Illinois.

More: Full Betting Guide for Southern Illinois vs. Northwestern

Southern Illinois vs. Northwestern Current Odds

• Spread: Northwestern -13.5 (-110), Southern Illinois +13.5 (-110)
• Moneyline: Northwestern -580, Southern Illinois +460
• Total: Over/Under 58 (-110/-110)

Point Spread, Moneyline and Over/Under

Northwestern is the -13.5 favorite versus Southern Illinois, with -110 at DraftKings Sportsbook the best odds currently available.

For the underdog Southern Illinois (+13.5) to cover the spread, DraftKings Sportsbook also has the best odds currently on the market at -110.

FanDuel Sportsbook currently has the best moneyline odds for Northwestern at -580, which means you can risk $580 to win $100, for a total payout of $680, if it gets the W.

On the other hand, DraftKings Sportsbook currently has the best moneyline odds for Southern Illinois at +460, where you can bet $100 to profit $460, earning a total payout of $560, if it wins.

The Over/Under for total points scored sits at 58 with DraftKings Sportsbook, which currently has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, check out all of the legal sportbooks available in your state for the best College Football odds and lines.

According to DimersBOT, Northwestern (-13.5) is a 52% chance of covering the spread, while the Over/Under total of 58 points is a 53% chance of going Under.

More: Live Win Probabilities for All Major College Sports

Best Bets for Southern Illinois vs. Northwestern

• Spread: Northwestern -13.5 @ -110 via DraftKings Sportsbook (52% probability)
• Moneyline: Southern Illinois @ +460 via DraftKings Sportsbook (1.0% edge)
• Total: Under 58 @ -110 via DraftKings Sportsbook (53% probability)

Dimers' best bets are based on complex modeling and wagering intelligence to serve you the best possible plays 24/7.

While Northwestern is more likely to win the game, according to DimersBOT, betting on Southern Illinois moneyline is the best option due to the 1.0% edge identified when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges published on Dimers is pivotal to achieving long-term profitability.

Southern Illinois vs. Northwestern Prediction

Dimers.com's predicted final score for Southern Illinois vs. Northwestern at Ryan Field this Saturday has Northwestern winning 35-21.

Click or tap on See Matchup for more.

Dimers has full betting coverage of this week's Southern Illinois-Northwestern matchup, including pregame predictions, top betting picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so keep an eye on this article for any changes to our betting analysis ahead of Southern Illinois vs. Northwestern on Saturday September 17, 2022.

Southern Illinois vs. Northwestern 2022 CFB Game Info

Saturday's matchup between Northwestern and Southern Illinois in College Football at Ryan Field is scheduled to start at 12:00PM ET.

• Who: Southern Illinois vs. Northwestern
• Date: Saturday September 17, 2022
• Time: 12:00PM ET / 9:00AM PT
• Venue: Ryan Field

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What other CFB games are on this week?

Southern Illinois and Northwestern aren't the only two NCAA Football teams you can bet on today. DimersBOT never stops and we've got picks and best bets for each and every CFB game via our College Football Predictions section.

Not only do we provide with you first-class predictions, but we also have recommended bets for the Spread, Over/Under and Moneyline. Sound good? Check it out now!