Southern California vs. California CFB Predictions and Odds - Dec 4, 2021

California squares off with Southern California in College Football Week 14 action at FTX Field at California Memorial Stadium on Saturday, starting at 11:00 PM EST.

Dimers' top betting picks for Southern California vs. California, plus our score prediction and best odds, are featured below.

Who will win Southern California vs. California?

Using advanced computer power and data, Dimers.com has simulated Saturday's Southern California-California NCAA Football matchup 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, gives California a 61% chance of defeating Southern California.

MORE: Full Betting Guide for Southern California vs. California

Point Spread, Moneyline and Over/Under

California is listed as the -4.5 favorite against Southern California, with -110 at Caesars Sportsbook the best odds available.

For the underdog Southern California (+4.5) to cover the spread, Caesars Sportsbook also has the best odds on offer at -110.

DraftKings Sportsbook has the best moneyline odds for California at -195. That means you can risk $195 to win $100, for a total payout of $295, if it gets the W.

On the other hand, FanDuel Sportsbook has the best moneyline odds for Southern California at +172, where you can put down $100 to profit $172, earning a total payout of $272, if it wins.

The Over/Under is set at 57.5 with Caesars Sportsbook, which has the best odds for the Over at -110, while FanDuel Sportsbook has the best odds for the Under at -108.

As always, make sure you check the sportsbooks you have access to in your state for the best College Football odds and lines.

According to DimersBOT, the bookmakers have got it right and both Southern California and California are a 50% chance of covering the spread, while the 57.5-point Over/Under is a 56% chance of going Over.

MORE: Predictions for Every College Football Week 14 Game

Best Bets for Southern California vs. California

• Spread: Southern California +4.5 at -110 with Caesars Sportsbook (50% probability)
• Moneyline: Southern California Win at +172 with FanDuel Sportsbook (2.4% edge)
• Over/Under: Over 57.5 at -110 with Caesars Sportsbook (56% probability)

While California is more likely to win the game, according to DimersBOT, betting on Southern California moneyline is the best option because of the 2.4% edge found when comparing our data-led probabilities to the sportsbooks' odds.

Taking advantage of the edges published on Dimers.com is one of the keys to being a profitable bettor in the long run.

Southern California vs. California Score Prediction

Dimers.com's predicted final score for Southern California vs. California at FTX Field at California Memorial Stadium this Saturday has California winning 29-25.

Use our interactive widget below to see the latest Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup to reveal more.

Dimers has full betting coverage of this week's Southern California-California matchup, including pre-game predictions, free picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so keep checking this page for any changes to our betting analysis before Southern California vs. California on Saturday December 4, 2021.

Southern California vs. California 2021 CFB Game Info

When does California play Southern California in College Football?

• Date: Saturday December 4, 2021
• Time: 11:00 PM EST / 8:00 PM PST
• Venue: FTX Field at California Memorial Stadium

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Want more College Football predictions like this?

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We use the power of predictive analytics to find value in the markets so we can write the most comprehensive CFB betting previews out there. We do this by comparing our in-house probabilities against the sportsbooks' odds (aka Vegas odds) as soon as they go live.

So, get ahead of the game and beat the 'books today – it's only a click away.