Mariners vs. Reds Prediction: Seattle Predicted to Win Wednesday's MLB Matchup [4/16/2025]

The Cincinnati Reds will take on the Seattle Mariners, in what is expected to be a tight MLB game, at Great American Ball Park on Wednesday, beginning at 6:40PM ET.

The Reds will send Nick Martinez (0-2, 6.06 ERA) to the mound, up against Bryce Miller (0-2, 4.50 ERA) for the Mariners.

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Mariners as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Seattle-Cincinnati game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Mariners' chance of winning at 51%, with the Reds at 49%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Mariners vs. Reds predictions page.

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Mariners vs. Mariners Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the outcome of Wednesday's MLB matchup between the Mariners and Reds 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Mariners a 51% chance of beating the Reds.

According to our model, the Reds (+1.5) have a 62% chance of covering the run line, while the over/under total of 8.5 runs has a 52% chance of going over.

Pre-Game Probabilities

Last Updated: 10:28PM, Apr 16

Moneyline

Over / Under

Run Line

Mariners

Win %

51%

49%

-110

-104

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Reds

Mariners SEA

-110

Win %

51%

49%

See Matchup

Reds CIN

-104

Bryce Miller 0-2, 4.50 ERA

Nick Martinez 0-2, 6.06 ERA

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Mariners vs. Reds Odds [4/16/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Mariners vs. Reds Picks and Best Bets

Our model's strongest edge in today's Mariners vs. Reds matchup is on the over/under.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free MLB Picks

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Mariners vs. Reds Game-Day Updates and Essential Details

Wednesday's MLB game between the Reds and Mariners at Great American Ball Park is scheduled to commence at 6:40PM ET.

• Who: Seattle Mariners vs. Cincinnati Reds
• Date: Wednesday, April 16, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Great American Ball Park

Dimers.com's in-depth preview of Wednesday's Mariners vs. Reds matchup includes our prediction, picks and the latest betting odds.

Before making any Seattle vs. Cincinnati picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Mariners, with a 51% win probability, will likely beat the Reds on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Mariners vs. Reds insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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