Mariners vs. Red Sox Prediction: Boston Predicted to Win Wednesday's MLB Matchup [4/23/2025]

The Boston Red Sox will square off with the Seattle Mariners in MLB action at Fenway Park on Wednesday, starting at 6:45PM ET.

The Red Sox will start Sean Newcomb (0-2, 3.64 ERA), pitting him against Emerson Hancock (0-1, 12.71 ERA) for the Mariners.

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Red Sox as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Seattle-Boston game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Red Sox' chance of winning at 59%, with the Mariners at 41%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Mariners vs. Red Sox predictions page.

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Red Sox vs. Mariners Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the result of Wednesday's MLB game between the Mariners and Red Sox 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Red Sox a 59% chance of defeating the Mariners.

According to our model, the Mariners (+1.5) have a 58% chance of covering the run line, while the over/under total of 9.5 runs has a 53% chance of going over.

Pre-Game Probabilities

Last Updated: 10:28PM, Apr 23

Moneyline

Over / Under

Run Line

Mariners

Win %

41%

59%

+120

-138

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Red Sox

Mariners SEA

+120

Win %

41%

59%

See Matchup

Red Sox BOS

-138

Emerson Hancock 0-1, 12.71 ERA

Sean Newcomb 0-2, 3.64 ERA

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Mariners vs. Red Sox Odds [4/23/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Mariners vs. Red Sox Picks and Best Bets

Our model's strongest edge in today's Mariners vs. Red Sox matchup is on the total.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Mariners vs. Red Sox Game-Day Updates and Essential Details

Wednesday's MLB game between the Red Sox and Mariners at Fenway Park is scheduled to begin at 6:45PM ET.

• Who: Seattle Mariners vs. Boston Red Sox
• Date: Wednesday, April 23, 2025
• Time: 6:45PM ET/3:45PM PT
• Venue: Fenway Park

Dimers.com's comprehensive preview of Wednesday's Mariners vs. Red Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Seattle vs. Boston picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Red Sox, with a 59% win probability, will likely beat the Mariners on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Mariners vs. Red Sox insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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