Mariners vs. Red Sox Prediction: Boston Predicted to Win Tuesday's MLB Matchup [4/22/2025]

MLB action continues on Tuesday at 6:45PM ET as the Seattle Mariners square off with the Boston Red Sox at Fenway Park.

Brayan Bello (0-0, 0.00 ERA) will get the ball for the Red Sox, while the Mariners have opted for Bryce Miller (1-2, 3.43 ERA).

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) projects the Red Sox as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's Seattle-Boston game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Red Sox with a win probability of 56%, compared to 44% for the Mariners."

For further insights into Tuesday's matchup, including best bets and picks, visit our interactive Mariners vs. Red Sox predictions page.

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Red Sox vs. Mariners Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data analysis, we have simulated the result of Tuesday's MLB game between the Mariners and Red Sox 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Red Sox a 56% chance of defeating the Mariners.

According to our model, the Mariners (+1.5) have a 63% chance of covering the run line, while the over/under total of 9.5 runs has a 57% chance of staying under.

Pre-Game Probabilities

Last Updated: 10:32PM, Apr 22

Moneyline

Over / Under

Run Line

Mariners

Win %

44%

56%

+105

-120

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Red Sox

Mariners SEA

+105

Win %

44%

56%

See Matchup

Red Sox BOS

-120

Bryce Miller 1-2, 3.43 ERA

Brayan Bello 0-0, 0.00 ERA

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Mariners vs. Red Sox Odds [4/22/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Mariners vs. Red Sox Picks and Best Bets

Our model's biggest edge in today's Mariners vs. Red Sox matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Mariners vs. Red Sox Game-Day Updates and Essential Details

Tuesday's MLB matchup between the Red Sox and Mariners at Fenway Park is scheduled to begin at 6:45PM ET.

• Who: Seattle Mariners vs. Boston Red Sox
• Date: Tuesday, April 22, 2025
• Time: 6:45PM ET/3:45PM PT
• Venue: Fenway Park

Dimers.com's in-depth preview of Tuesday's Mariners vs. Red Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Seattle vs. Boston picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Red Sox, with a 56% win probability, will likely beat the Mariners on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Mariners vs. Red Sox insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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