Seahawks vs. 49ers Week 2 Prediction and Odds - Sep 18, 2022

The San Francisco 49ers face the Seattle Seahawks in NFL Week 2 action at Levi's Stadium on Sunday, commencing at 4:05PM ET.

Dimers' top betting picks for Seahawks vs. 49ers, plus our score prediction, betting odds and touchdown scorer probabilities, are featured in this article.

Today's Seattle vs. San Francisco betting preview is brought to you by FanDuel Sportsbook, which has a tasty No Sweat First Bet promo for new customers.

Who will win Seahawks vs. 49ers?

Based on cutting-edge computer power and data, Dimers.com has simulated Sunday's Seahawks-49ers NFL game 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, currently gives the 49ers an 80% chance of getting the W against the Seahawks in Week 2 of the NFL season.

More: Seahawks vs. 49ers Simulated 10,000 Times

Seahawks vs. 49ers Game Odds

• Spread: 49ers -8.5 (-105), Seahawks +8.5 (-110)
• Moneyline: 49ers -365, Seahawks +325
• Total: Over/Under 39.5 (-107/-107)

Point Spread, Moneyline and Over/Under

The 49ers are currently -8.5 favorites versus the Seahawks, with -105 at FanDuel Sportsbook the best odds currently available.

For the underdog Seahawks (+8.5) to cover the spread, Caesars Sportsbook has the best odds currently on offer at -110.

DraftKings Sportsbook currently has the best moneyline odds for the 49ers at -365, which means you can risk $365 to win $100, for a total payout of $465, if they get the W.

Elsewhere, BetMGM currently has the best moneyline odds for the Seahawks at +325, where you can bet $100 to profit $325, earning a total payout of $425, if they win.

The Over/Under sits at 39.5 with PointsBet, which currently has the best odds for the Over at -107, as well as the best odds for the Under at -107.

As always, check out all the legal sportbooks available in your state for the best NFL odds and lines.

According to DimersBOT, the Seahawks (+8.5) are a 52% chance of covering the spread, while the 39.5-point Over/Under is a 56% chance of going Over.

More: Free Prop Picks

Best Bets for Seahawks vs. 49ers

• Spread: Seahawks +8.5 @ -110 via Caesars Sportsbook (52% probability)
• Moneyline: 49ers @ -365 via DraftKings Sportsbook (80% probability)
• Total: Over 39.5 @ -107 via PointsBet (56% probability) 🔥

Any time you see a 🔥, that means you've found one of Dimers' best bets today across all major pro and college sports.

Dimers' best bets are based on complex simulations and gambling expertise to bring you the best possible plays every day of the year.

Seahawks vs. 49ers Prediction

Dimers.com's predicted final score for Seattle vs. San Francisco at Levi's Stadium in Week 2 has the 49ers winning 24-16.

Click or tap on See Matchup for more.

Dimers has full coverage of this week's Seahawks-49ers matchup in Week 2, including pregame predictions, free betting picks, and live win probabilities.

Seahawks vs. 49ers Player Props

Who will score the first touchdown in Seahawks vs. 49ers? The data is in.

Featured below are the most likely first touchdown and most likely anytime touchdown scorers for both the Seahawks and 49ers, as well as player stat projections.

And you know what, we provide this information to you for FREE to help you select the best prop picks for Sunday's game.

According to DimersBOT, San Francisco's Deebo Samuel is most likely to score the first touchdown in Seahawks vs. 49ers.

DimersBOT gives Samuel an 11.1% chance of getting in for six first at Levi's Stadium, while the 49ers WR is a 43.3% chance of scoring an anytime touchdown.

Scroll down for our full list of first and anytime TD scorer probabilities.

First Touchdown Scorer Probabilities

Seattle Seahawks

• Rashaad Penny: 8.4% probability
• DK Metcalf: 6.8% probability
• Tyler Lockett: 5.9% probability
• Kenneth Walker: 4.6% probability
• Will Dissly: 4.3% probability

San Francisco 49ers

• Deebo Samuel: 11.1% probability
• Trey Lance: 8.2% probability
• Brandon Aiyuk: 8.0% probability
• Jeff Wilson: 7.7% probability
• Jauan Jennings: 4.8% probability

Anytime Touchdown Scorer Probabilities

Seattle Seahawks

• Rashaad Penny: 33.2% probability
• DK Metcalf: 27.5% probability
• Tyler Lockett: 24.6% probability
• Kenneth Walker: 19.0% probability
• Will Dissly: 18.2% probability

San Francisco 49ers

• Deebo Samuel: 43.3% probability
• Trey Lance: 33.6% probability
• Brandon Aiyuk: 32.1% probability
• Jeff Wilson: 31.4% probability
• Jauan Jennings: 20.6% probability

Seahawks-49ers Projected Player Stats

Of the starting quarterbacks, the Seahawks' Geno Smith is projected for 229 passing yards. The 49ers' Trey Lance is expected to throw for 216 yards.

Seahawks Starting QB

• Geno Smith: 229 projected yards

49ers Starting QB

• Trey Lance: 216 projected yards

Seahawks Rushing

• Rashaad Penny: 72 projected yards
• Kenneth Walker: 32 projected yards
• Geno Smith: 16 projected yards

49ers Rushing

• Jeff Wilson: 55 projected yards
• Trey Lance: 33 projected yards
• Deebo Samuel: 25 projected yards

Seahawks Receiving

• Tyler Lockett: 58 projected yards
• DK Metcalf: 50 projected yards
• Will Dissly: 29 projected yards
• Marquise Goodwin: 28 projected yards
• Noah Fant: 22 projected yards

49ers Receiving

• Brandon Aiyuk: 59 projected yards
• Deebo Samuel: 49 projected yards
• Jauan Jennings: 25 projected yards
• Ross Dwelley: 20 projected yards
• Kyle Juszczyk: 18 projected yards

Remember, DimersBOT updates regularly, so refresh this page for the latest betting analysis ahead of Seahawks vs. 49ers on Sunday September 18, 2022.

Seahawks vs. 49ers 2022

The NFL Week 2 action between the 49ers and Seahawks at Levi's Stadium is scheduled to start at 4:05PM ET.

• Who: Seattle Seahawks vs. San Francisco 49ers
• Date: Sunday September 18, 2022
• Time: 4:05PM ET / 1:05PM PT
• Venue: Levi's Stadium

Want to join an online sportsbook and start betting on the NFL? Check out the best sports betting sign-up offers in your state.

What NFL games are on today?

The Seahawks and 49ers aren't the only two NFL teams you can bet on. DimersBOT never stops and we've got picks and best bets for each and every NFL game in our NFL Bet Hub page.

Not only do we provide with you great predictions, but we also have recommended bets for the Spread, Over/Under and Moneyline. Sound good? Hell yeah it does!